Text Size

Scientific Evaluation of Peer Education and STD Treatment to Reduce the Spread of HIV in Zimbabwe

This study has been completed.
Sponsor:
Collaborator:
Biomedical Research and Training Institute
Information provided by:
Imperial College London
ClinicalTrials.gov Identifier:
NCT00390949
First received: October 20, 2006
Last updated: January 9, 2007
Last verified: October 2006
History of Changes
  Purpose

The purpose of this study is to determine whether community-based peer education and condom distribution combined with improved treatment of sexually transmitted infections are effective in reducing the spread of HIV infection in a sub-Saharan African population


Condition Intervention
HIV Infections
 Behavioral: Peer education among commercial sex workers and clients
Behavioral: Condom distribution and promotion
Procedure: Syndromic treatment of sexually transmitted infections
Procedure: Systemic counselling for STI patients

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Prevention
Official Title: Impact and Process Evaluation of Integrated Community and Clinic-Based HIV-1 Control: a Cluster-Randomised Trial in Eastern Zimbabwe

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Imperial College London:

Primary Outcome Measures:
  • HIV incidence at the community level

Secondary Outcome Measures:
  • Self-reported genital ulcers
  • Self-reported urethral or genital discharge
  • Sexually transmitted infection treatment effectiveness (self-reported cessation of symptoms)
  • Sexual behaviour change (sexual debut, sexual partner change, non-regular partners, unprotected sex with regular and casual partners)
  • Health-seeking behaviour change
  • HIV/AIDS knowledge

Study Start Date: July 1998
Estimated Study Completion Date: February 2003
  Show Detailed Description

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • All members of study communities
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00390949

Locations
Zimbabwe
Biomedical Research and Training Institute
Harare, Zimbabwe
Sponsors and Collaborators
Imperial College London
Biomedical Research and Training Institute
Investigators
Principal Investigator: Simon Gregson, DPhil Imperial College London
Principal Investigator: Stephen Chandiwana, PhD Biomedical Research and Training Institute
  More Information

Additional Information:
Department of Infectious Disease Epidemiology, Imperial College London  This link exits the ClinicalTrials.gov site
Biomedical Research and Training Institute, Harare  This link exits the ClinicalTrials.gov site

Publications:

ClinicalTrials.gov Identifier: NCT00390949     History of Changes
Other Study ID Numbers: PC3239_DFID
Study First Received: October 20, 2006
Last Updated: January 9, 2007
Health Authority: United Kingdom: Research Ethics Committee

Keywords provided by Imperial College London:
HIV prevention
Zimbabwe
Core groups
Peer education
 Syndromic management
Commercial sex workers
Condom distribution
HIV Seronegativity

Additional relevant MeSH terms:
HIV Infections
Acquired Immunodeficiency Syndrome
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
 Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
Slow Virus Diseases

ClinicalTrials.gov processed this record on May 23, 2013