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Molecular Epidemiology of Benzene-exposed Workers.

This study has been completed.
Sponsor:
Collaborators:
Fudan University
University of Cincinnati
ExxonMobil Biomedical Sciences, Inc.
British Petroleum-Amoco
Chevron
ConocoPhillips
Exxon Mobil
Marathon Ashland
Shell Chemicals
Information provided by (Responsible Party):
University of Colorado, Denver
ClinicalTrials.gov Identifier:
NCT00364520
First received: August 14, 2006
Last updated: February 5, 2013
Last verified: May 2007
History of Changes
  Purpose

The purpose of this study is to investigate the health effects of benzene exposure in workers in Shanghai, China.


Condition Intervention
Hematologic Diseases
 Other: Shanghai workers

Study Type: Observational
Study Design: Observational Model: Ecologic or Community
Time Perspective: Cross-Sectional
Official Title: Molecular Epidemiology of Benzene-exposed Workers in Shanghai,China

Resource links provided by NLM:

MedlinePlus related topics: Blood Disorders
U.S. FDA Resources

Further study details as provided by University of Colorado, Denver:

Primary Outcome Measures:
  • Investigate the dose-response relationship between benzene exposure and blood diseases in Shanghai workers. [ Time Frame: August 2003 - December 2009 ] [ Designated as safety issue: No ]
    Investigate the dose-response relationship between benzene exposure and blood diseases in Shanghai workers


Secondary Outcome Measures:
  • Characterize genetic polymorphisms that are associated with increased risk of developing benzene hematotoxicity. [ Time Frame: August 2003 - December 2009 ] [ Designated as safety issue: No ]
    Characterize genetic polymorphisms that are associated with increased risk of developing benzene hematotoxicity.


Enrollment: 2000
Study Start Date: August 2003
Study Completion Date: December 2009
Primary Completion Date: December 2009 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Shanghai Workers
Shanghai Workers
 Other: Shanghai workers

Detailed Description:

The purpose of this study is to investigate the dose-response relationship between benzene exposure and blood diseases in Shanghai workers and to characterize genetic polymorphisms that are associated with increased risk of developing benzene hematotoxicity.

  Eligibility

Ages Eligible for Study:   18 Years to 67 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Shanghai Workers

Criteria

Inclusion Criteria:

Worked for at least one year in a monitored environment Have at least one physical examination recorded

-

Exclusion Criteria:

History of cancer, radiation exposure, chemotherapy

-

  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00364520

Locations
China
Joint Sino-US Clinical and Molecular Laboratory (JCML)
Shanghai, China, 200032
Sponsors and Collaborators
University of Colorado, Denver
Fudan University
University of Cincinnati
ExxonMobil Biomedical Sciences, Inc.
British Petroleum-Amoco
Chevron
ConocoPhillips
Exxon Mobil
Marathon Ashland
Shell Chemicals
Investigators
Principal Investigator: Richard D Irons, PhD University of Colorado at Denver and Health Sciences Ctr
  More Information

No publications provided

Responsible Party: University of Colorado, Denver
ClinicalTrials.gov Identifier: NCT00364520     History of Changes
Other Study ID Numbers: 02-037
Study First Received: August 14, 2006
Last Updated: February 5, 2013
Health Authority: United States: Institutional Review Board
China: Ministry of Health

Keywords provided by University of Colorado, Denver:
Hematologic Diseases
Benzene
Genetic Polymorphisms

Additional relevant MeSH terms:
Hematologic Diseases

ClinicalTrials.gov processed this record on May 16, 2013