Atrial Fibrillation and the Risk for Neurological Complications

The recruitment status of this study is unknown because the information has not been verified recently.
Verified April 2007 by University Hospital Muenster.
Recruitment status was  Recruiting
Sponsor:
Collaborator:
German Federal Ministry of Education and Research
Information provided by:
University Hospital Muenster
ClinicalTrials.gov Identifier:
NCT00357227
First received: July 25, 2006
Last updated: April 18, 2007
Last verified: April 2007
  Purpose

B8: Atrial fibrillation and the risk of neurological complications

Twenty-five thousand acute strokes are caused by atrial fibrillation every year. But even more frequent than symptomatic strokes are silent infarctions of the brain. Silent strokes remain undetected in most cases, but cumulate over time and progressively impair cognition. The impact of atrial fibrillation on subacute brain infarctions is not yet known. Moreover, it has not been elucidated so far how effective different therapeutic strategies in the treatment of atrial fibrillation prevent cognitive impairment. Thus, this study aims at evaluating the influence of different types of atrial fibrillation on silent strokes and the related impairment in cognitive functions. Other risk factors and cardiovascular diseases that are known to provoke the development of strokes will be assessed as well. So, it will be possible to isolate the contribution of atrial fibrillation to silent strokes and related cognitive impairment in segregation to other relevant factors. AF patients and controls will be examined twice in two years in order to evaluate the role of atrial fibrillation and differential therapeutic interventions with regard to the progression of silent strokes and cognitive impairment in a within subject-design.


Condition Phase
Atrial Fibrillation
Phase 4

Study Type: Observational
Study Design: Observational Model: Defined Population
Time Perspective: Longitudinal
Official Title: Atrial Fibrillation and the Risk for Neurological Complications

Resource links provided by NLM:


Further study details as provided by University Hospital Muenster:

Estimated Enrollment: 1000
Study Start Date: January 2004
  Eligibility

Ages Eligible for Study:   50 Years to 85 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Clinical diagnosis of permanent, paroxysmal or episodic atrial fibrillation in the past or at present

Exclusion Criteria:

  • Pacemaker
  • Metal implants
  • History of acute stroke
  • Diagnosis of vascular or degenerative dementia
  • History of brain tumors
  • History of severe brain injury
  • History of psychiatric disorders
  • Pregnancy
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00357227

Contacts
Contact: Stefan Knecht, Prof. +49-251-83- ext 48195 knecht@uni-muenster.de

Locations
Germany
University Hospital Münster, Dept. of Neurology Recruiting
Münster, NRW, Germany, 48149
Principal Investigator: Stefan Knecht, Prof.         
Sponsors and Collaborators
University Hospital Muenster
German Federal Ministry of Education and Research
Investigators
Principal Investigator: Stefan Knecht, Prof. University Hospital Münster, Department of Neurology
  More Information

Additional Information:
No publications provided

ClinicalTrials.gov Identifier: NCT00357227     History of Changes
Other Study ID Numbers: 01 GI 0204
Study First Received: July 25, 2006
Last Updated: April 18, 2007
Health Authority: Germany: Ethics Commission

Keywords provided by University Hospital Muenster:
Atrial fibrillation
Stroke
Vascular Dementia
Mild Cognitive Impairment

Additional relevant MeSH terms:
Atrial Fibrillation
Arrhythmias, Cardiac
Heart Diseases
Cardiovascular Diseases
Pathologic Processes

ClinicalTrials.gov processed this record on July 28, 2014