Biological Functions of Carotenoids in Humans
This study will examine the the efficiency fo absorption of major plant pigments, carotenoids, (lutein, beta-carotene and lycopene)and will measure the biological functions of carotenoids in healthy women in response to an 8-week period of carotenoid supplementation.
The antioxidant capacity (in both the aqueous and lipid compartments), DNA oxidation (single cell gel electrophoresis), Insulin-like Growth Factor (IGF-1), Insulin-like Growth Factor Binding Protein-3 (IGFBP-3), (gene expression profile (high-density filter-based cDNA microarrays), lipid peroxidation (MDA analysis and Isoprostane determination), and antioxidant nutrient levels (carotenoids, tocopherols, ascorbic acid and uric acid) in the circulation will be measured every other week throughout the study period.
|Study Design:||Allocation: Randomized
Endpoint Classification: Bio-availability Study
Intervention Model: Single Group Assignment
Primary Purpose: Prevention
|Official Title:||Functional Bioavailability of Carotenoids in Humans|
|United States, Massachusetts|
|Jean Mayer USDA-Human Nutrition Research Center on Aging, Tufts University|
|Boston, Massachusetts, United States, 02111|
|Principal Investigator:||Kyung-Jin Yeum, PhD||Tufts Medical Center|