Inclusion Criteria:

• Subjects must have a body mass index (BMI) of 18 to 30 kg/m2, inclusive (BMI = weight (kg)/[height (m)]2) and weigh at least 50 kg.
• Males or females, ages > 18 to < 65 years.

• Women of childbearing potential (WOCBP) must not be nursing or pregnant. All women of childbearing potential (have not reached menopause nor undergone hysterectomy, bilateral oophorectomy, or tubal ligation) must have a negative serum beta-HCG test performed at screening (within 24 hours before the start of study day 1). Female subjects who are not of reproductive potential (have reached menopause or undergone hysterectomy, bilateral oophorectomy, or tubal ligation) or whose male partner has undergone successful vasectomy with resultant azoospermia or has azoospermia for any other reason, are eligible without requiring the use of contraception. Documentation of menopause, sterilization (hysterectomy, oophorectomy, tubal ligation, or vasectomy) and azoospermia by patient-reported history is acceptable. Both male and female study volunteers of reproductive potential must agree not to participate in a conception process (i.e., active attempt to become pregnant or to impregnate via sperm donation or in vitro fertilization), and, if participating in sexual activity that could lead to pregnancy, the female study volunteer/male partner must use a form of contraception as specified below while receiving protocol-specified medication(s) and for one month after stopping the medication(s). Male study volunteers will be required to use a barrier method for at least 3 months after completion of the study.

  • Condoms (male or female) with or without a spermicidal agent
  • Diaphragm or cervical cap with spermicide

Exclusion Criteria:

• History or current evidence of any significant acute or chronic medical illness that, within the investigator's discretion, would interfere with the conduct or interpretation of the study.
• History of acute or chronic pancreatitis.
• History of diabetes mellitus, hypertriglyceridemia, or chronic renal insufficiency.
• Proven or suspected acute hepatitis at the time of study entry.
• Current or recent (within 3 months) gastrointestinal disease which would interfere with the conduct or interpretation of the study.
• Any major surgery within 4 weeks of enrollment. Any gastrointestinal surgery that could impact upon the absorption of study drug.
• Donation of blood or plasma to a blood bank or in a clinical study (except a screening visit) within 4 weeks of enrollment.
• Inability to tolerate oral medication.
• Inability to tolerate venipuncture and/or absence of secure venous access.
• Known or suspected HIV infection or chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection
• Known active drug or alcohol abuse which, in the opinion of the investigator, makes study participation to completion unlikely.
• Any other sound medical, psychiatric, and/or social reason, as determined by the investigator.
• Subjects with AST, ALT, or bilirubin above the upper limit of normal.
• Hemoglobin < 9.5 g/dL, and platelet count < 100,000/mm3.
• Subjects with creatine phosphokinase (CPK) elevation greater than 3 times the upper limit of normal.
• Any other clinically significant screening lab abnormality (as determined by the investigator)
• History of any significant drug allergy, drug rash, or sensitivity to any class of drugs relevant to the study drugs.
• Prior exposure to tipranavir/ritonavir.
• Exposure to any investigational drug within 4 weeks of enrollment and throughout the study.
• Any previous hypersensitivity or intolerance to tipranavir or ritonavir or any other ingredient of Aptivus or Norvir.
• Hypersensitivity to sulfonamides
• Any previous hypersensitivity or intolerance to rosuvastatin or any other ingredient of Crestor (rosuvastatin).
• Known elevated liver enzymes in past clinical trials with any compound
• Use of any agent, within 2 weeks of dosing, that is known to induce or inhibit drug metabolizing enzymes
• Use of any over-the-counter drugs, including antacids, alternative herbal products, or prescription drugs that, in the opinion of the investigator, might interfere with the absorption, distribution, or metabolism of TPV, RTV, or rosuvastatin within 14 days of study entry.