The Effect of Ribose on B-Type Natriuretic Peptide (BNP) Levels in Congestive Heart Failure Patients
The purpose of this research study is to test the effectiveness of CORvalen, a medical food, to increase cellular energy sufficiently to change or modify BNP levels in congestive heart failure patients.
|Study Design:||Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
|Official Title:||The Effect of Ribose on B-Type Natriuretic Peptide Levels in Congestive Heart Failure Patients|
- Demonstrate a significant reduction in serial BNP values over 3 months while on ribose supplementation
- Demonstrate significant improvement in serial six minute hall walks while on ribose supplementation
- Demonstrate significant improvement in quality of life as measured by the Minnesota, Living with Heart Failure Questionnaire.
|Study Start Date:||June 2006|
|Study Completion Date:||July 2007|
B-type natriuretic peptide (BNP), is a blood test commonly used to track the progress of congestive heart failure. CORvalen, a medical food, contains D-Ribose (ribose), a natural substance that has been shown to improve the amount of energy compounds at the cellular level. Congestive heart failure has been associated with a reduced level of high-energy compounds. One researcher has called them an "energy starvation" in congestive heart failure. This study will try to assess if increasing the amount of these energy compounds is sufficient to improve BNP levels. Approximately 120 symptomatic congestive heart failure patients will participate in this 3 month study.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00329485
|United States, Ohio|
|See list of Study Principal Investigators|
|Columbus, Ohio, United States|
|Principal Investigator:||Garrie Haas, MD||Ohio State University|
|Principal Investigator:||Mark Munger, PharmD||University of Utah|
|Principal Investigator:||Reynolds Delgado, MD||Texas Heart Institute|
|Principal Investigator:||Daniel Pauly, MD, PhD||University of Florida|
|Principal Investigator:||Kris Vijay, MD||Scottsdale Cardiovascular Research Institute|
|Principal Investigator:||Masoor Kamalesh, MD||Roudebush VA Medical Center|
|Principal Investigator:||Robert J Weiss, MD||Maine Research Associates|