The Effects of Levetiracetam on Alcohol Dependent Subjects

The recruitment status of this study is unknown because the information has not been verified recently.
Verified April 2007 by Boston University.
Recruitment status was  Active, not recruiting
Sponsor:
Collaborator:
UCB Pharma
Information provided by:
Boston University
ClinicalTrials.gov Identifier:
NCT00325182
First received: May 11, 2006
Last updated: April 4, 2007
Last verified: April 2007
  Purpose

This study will attempt to examine whether Levetiracetam (Keppra (TM)) can help people with alcohol dependence cut down on their alcohol consumption. In addition, the investigation will assess the effectiveness of Keppra on reducing withdrawal symptoms post alcohol cessation. Matched group of historical controls of alcohol dependent patients receiving placebo will be used for comparison.Based on the mechanism of action of Keppra we hypothesize that it may be effective in promoting abstinence and reducing drinking behavior in alcohol dependent patients.


Condition Intervention Phase
Alcoholism
Drug: Keppra (Levetiracetam)
Phase 4

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: The Effects of Levetiracetam on Alcohol Dependent Subjects

Resource links provided by NLM:


Further study details as provided by Boston University:

Primary Outcome Measures:
  • The primary outcome of this study will be determined by comparing the mean drinks consumed per day at baseline compared with the mean drinks per day consumed during week 11 of the treatment period.

Secondary Outcome Measures:
  • Mean heavy drinks per drinking day, OCDS scores, MOS-Sleep Scores, and POMS scores.

Estimated Enrollment: 50
Study Start Date: January 2006
Estimated Study Completion Date: July 2007
Detailed Description:

Alcoholism is a chronic disease with numerous psychological, social and medical consequences. Alcohol use disorders are one of the most prevalent psychiatric disorders in general population in the US. Alcoholism not only disrupts an individual's life, health and ability to function in the society, has tremendous impact on families and communities, but also is associated with enormous economic cost for society. The medical and social impact of alcoholism can be reduced via effective treatments. Although medical, psychological and social approaches have demonstrated some efficacy, no specific method has consistently shown superiority. Similarly, currently available pharmacological treatments for alcohol use disorders are associated with moderate efficacy, indicating that further efforts are required to develop novel interventions.

The rewarding effects of alcohol are at least partially mediated via dopamine pathways that originate in the ventral tegmental area and project to the nucleus accumbens. Alcohol through its effects on GABA receptor activity decreases the inhibitory effect of GABA on the dopaminergic neurons in ventral tegmental area and therefore facilitates dopamine neurotransmission. Medications that modulate excitatory neurotransmission in the brain (glutamate) and facilitate inhibitory effects of GABA have been shown to be clinically effective in treatment of alcoholism.

Keppra is a novel antiepileptic medication currently approved for treatment of partial onset seizures as an adjunctive agent. It has a unique mechanism of action in that it reduces negative allosteric effects of Zn++ and Beta- carboline in two main inhibitory receptors in the CNS- the GABA A and glycine receptors. These modulators inhibit the influx of chloride though both of these receptor complexes and are therefore considered excitatory mediators. Keppra prevents the negative modulation and promotes chloride flux, thereby, inhibiting neurotransmission.

Limited laboratory work with levetiracetam (Keppra) has shown that the medication can reverse the anxiogenic effect of benzodiazepine withdrawal in mice (Y. Lamberty et al., 2002). Furthermore, Keppra was investigated for its potential to prevent alcohol withdrawal symptoms in mice. In this study levetiracetam dose-dependently prevented spontaneous tremors and handling induced convulsions in alcohol dependent mice. (Y. Lamberty et al., 2002). Based on the mechanism of action of Keppra we hypothesize that it may be effective in promoting abstinence and reducing drinking behavior in alcohol dependent patients.

  Eligibility

Ages Eligible for Study:   21 Years to 60 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • DSM IV TR Diagnosis of Alcohol Dependence
  • Male or female age 21-60 years old
  • Able to provide informed consent and comprehend study procedures
  • Negative urine toxicological screen for narcotics, amphetamines, sedative hypnotics and cannabinoids. The test may be repeated within a week.
  • Score of > 8 on Alcohol Use Disorder Identification Test during screening
  • Must be suitable for outpatient management
  • Express desire to stop drinking or reduce alcohol consumption with possible long-term goal of abstinence.
  • Provide contact information for themselves or an alternate contact that the study staff will contact in case of missed appointment.
  • Female subjects must be postmenopausal for at least one year, or practicing an effective method of birth control before entry and throughout the study
  • Must be able to take oral medications, adhere to regimen and be willing to return for follow up visits
  • Must have breath alcohol concentration of no more than 0.025% when signing the informed consent

Exclusion criteria:

  • Dependent on or extensive abuse of drugs or substances other than ethanol, nicotine or caffeine
  • DSM IV- TR diagnosis of any current Axis I diagnosis other than alcohol, nicotine or caffeine dependence that in the investigator's judgment might require intervention with either pharmacological or non-pharmacological therapy that might interfere with the course of the study
  • Receiving inpatient or outpatient treatment for alcohol dependence (with the exception of AA or other self-help groups) within the 4 weeks prior to enrollment
  • Subjects with a score of 10 or greater on the CIWA-Ar at visits one and two
  • Currently being treated with disulfiram or naltrexone
  • Currently being treated with any the following medications: a) Antipsychotic agent [b) Lithium Carbonate c) Anticonvulsant agent d) Hypnotics e) Antianxiety Agents f) Chronic opiate treatment with methadone, laam, buprenorphine; oxycodone, morphine, etc g) Stimulant treatment
  • Subjects who are legally mandated to participate in alcohol treatment program
  • Subjects who have had a suicide attempt or suicidal ideation within 30 days of the first visit
  • Subjects with renal disease
  • Subjects with AST and ALT >3 times the upper limit of the normal range during screening. Test may be repeated prior to enrollment. If repeat lab values are all within acceptable ranges subject may continue study participation.
  • Major neurological disorder including seizures
  • Subjects who are pregnant or lactating
  • Subjects known to have clinically significant medical conditions, including, but not limited to: symptomatic CAD or PVD, malignancy or history of malignancy in the last 5 years, pulmonary disorders, endocrinological disorders
  • Subjects with prior hypersensitivity to Keppra
  • Subjects with history of medically complicated withdrawal from alcohol.
  • Subjects who in the opinion of the investigator should not be enrolled in the study because of the precautions, warnings and contraindications outlined in the Keppra package insert
  • Subjects with cardiac pacemaker or metal surgical implant
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00325182

Locations
United States, Massachusetts
Boston University Dept of Psychiatry Clinical Studies Unit
Boston, Massachusetts, United States, 02118
Sponsors and Collaborators
Boston University
UCB Pharma
Investigators
Principal Investigator: Ofra Sarid-Segal, MD Boston University
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00325182     History of Changes
Other Study ID Numbers: H-23008
Study First Received: May 11, 2006
Last Updated: April 4, 2007
Health Authority: United States: Institutional Review Board

Keywords provided by Boston University:
Alcoholism

Additional relevant MeSH terms:
Alcoholism
Alcohol-Related Disorders
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders
Etiracetam
Piracetam
Anticonvulsants
Central Nervous System Agents
Therapeutic Uses
Pharmacologic Actions
Nootropic Agents
Neuroprotective Agents
Protective Agents
Physiological Effects of Drugs

ClinicalTrials.gov processed this record on September 16, 2014