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Computer-Based Training for Mild Alzheimer's Disease

This study has been completed.
Sponsor:
Collaborator:
University of California, San Francisco
Information provided by:
Posit Science Corporation
ClinicalTrials.gov Identifier:
NCT00319891
First received: April 27, 2006
Last updated: May 13, 2013
Last verified: May 2013
History of Changes
  Purpose

The primary objective of this study is to evaluate the effects of computer-based training program ("HiFi-AD") on the memory and cognitive abilities of individuals diagnosed with mild Alzheimer's Disease (AD).


Condition Intervention Phase
Alzheimer's Disease
 Procedure: Computer-based Cognitive Training
 Phase 1

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Computer-Based Training for Mild Cognitive Impairment and Mild Alzheimer's Disease

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Posit Science Corporation:

Primary Outcome Measures:
  • The primary objective of this trial will be to assess the feasibility of using computer-based
  • cognitive training in an a population with early Alzheimer's Disease.

Secondary Outcome Measures:
  • A standardized set of neuropsychological assessments will be conducted pre- and post-
  • compuer-based training.

Estimated Enrollment: 6
Study Start Date: September 2004
Estimated Study Completion Date: October 2006
Primary Completion Date: October 2006 (Final data collection date for primary outcome measure)
Detailed Description:

The purpose of this study is to determine the extent to which computer-based cognitive remediation improves cognitive functions using standardized neuropsychological assessments relevant to AD; 2) the acceptability and feasibility of using computer-based cognitive remediation in an AD population.

  Eligibility

Ages Eligible for Study:   60 Years to 90 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Fluent in English.
  • Mini-Mental Status Examination (MMSE) score of 22 or higher.
  • Adequate visual capacity.
  • Adequate hearing capacity.
  • Has a caregiver with some computer experience.
  • Willing and able to commit to the time requirement of the entire study.

Exclusion Criteria:

  • Clinically significant cerebrovascular disease.
  • Participant is planning to begin acetylcholinesterase inhibitor (AChEI) therapy.
  • Participants with severe tremor.
  • Axis 1 or 2 psychiatric disorders.
  • History of substance abuse.
  • History of head trauma.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00319891

Locations
United States, California
University of California, San Francisco
San Francisco, California, United States, 94143
Sponsors and Collaborators
Posit Science Corporation
University of California, San Francisco
Investigators
Principal Investigator: Joel Kramer, PsyD University of California, San Francisco
Principal Investigator: Kristine Yaffe, MD University of California, San Francisco
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00319891     History of Changes
Other Study ID Numbers: OUT-109-2005
Study First Received: April 27, 2006
Last Updated: May 13, 2013
Health Authority: United States: Food and Drug Administration

Keywords provided by Posit Science Corporation:
Alzheimer's
AD
Mild Cognitive Impairment
 Dementia
Cognitive remediation
computer-based training

Additional relevant MeSH terms:
Alzheimer Disease
Dementia
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
 Tauopathies
Neurodegenerative Diseases
Delirium, Dementia, Amnestic, Cognitive Disorders
Mental Disorders

ClinicalTrials.gov processed this record on May 21, 2013