Identification of Cytokine Profiles and T Cell Subsets Among Immunosuppressed Patients at Risk of Developing Active Tuberculosis
Recruitment status was Recruiting
The purpose of this study is to identify differences in TB specific immune responses among immunosuppressed patients latently infected with TB and patients with active TB.
|Study Design:||Observational Model: Defined Population
Time Perspective: Longitudinal
|Study Start Date:||November 2005|
|Estimated Study Completion Date:||September 2008|
Immunosuppressed patients latently infected with TB are at higher risk of developing active TB than patients with normal immune functions. Especially two patient categories are at risk: HIV positives and patients receiving TNF-a blocking medication. Existing methods of diagnosis and surveillance of latent TB infection can not identify who will develop active TB and who can control the infection. There is a need for better understanding of TB specific immune functions,as we believe deficient TB specific immune reactions is a key in reactivation of latent TB infection.
In this study we follow groups of latent TB infected patients with either rheumatoid arthritis or HIV. We follow the patients during treatment with TNF-a blocking medication, HAART treatment or prophylactic TB medication. Results are correlated to patients with active TB, latent TB and healthy controls.
|Contact: Morten Ruhwald, MD||+45 email@example.com|
|Contact: Pernille Ravn, MD, Ph.d.||+45 firstname.lastname@example.org|
|Infectious disease department University Hospital Hvidovre||Recruiting|
|Copenhagen, Denmark, 2650|
|Principal Investigator:||Morten Ruhwald, MD||University Hospital Hvidovre|