Effect of Exercise Intervention on Various Physiologic Factors That Change With Increasing Age
This study randomized healthy sedentary people age 20-80 years to 16 weeks of supervised exercise versus no exercise. Several end points were evaluated after 16 weeks including insulin sensitivity and muscle physiology.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind
|Official Title:||Impact of Aerobic Exercise Training on Age Related Changes in Insulin Sensitivity and Muscle Oxidative Capacity|
- Insulin sensitivity
- Muscle Mitochondrial Protein Synthesis
- mRNA of mitochondrial genes
- mRNA of genes involved in mitochondrial biogenesis
|Study Start Date:||September 1995|
|Study Completion Date:||January 1998|
|Primary Completion Date:||January 1998 (Final data collection date for primary outcome measure)|
Healthy subjects performing < 30 min exercise twice per week were studied prior to randomization and after of sixteen weeks exercise. They were randomized to sixteen weeks of supervised exercise performed on a stationary bike vs. placebo exercise (a series of flexibility exercises performed at home). Intensity, duration and frequency of exercise were gradually increased to four sessions per week lasting forty minutes each and achieving 80% target heart rate. Participants were weighed perioidically and counseled appropriately when weight changed by > 2 %. Insulin sensitivity and muscle mitochondrial protein synthesis were studied.