The Effects of Marijuana on Orientation and Motor Coordination and Brain Metabolism in Regular Smokers of Marijuana
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Purpose
This study investigates the effects of 17mg and 13mg Delta THC on orientation and motor coordination and brain metabolic activity in regular users of marijuana. Subjects were tested twice, after smoking cigarettes with marijuana and after smoking cigarettes without marijuana.On both occasions they performed on a virtual reality maze task. They were afterwards scanned in Positron Emission Tomography (PET) with Fluoro-deoxy-glucose (FDG).
| Condition | Intervention |
|---|---|
|
Marijuana Dependence |
Drug: Tetra Hydro Cannabinol (THC) |
| Study Type: | Interventional |
| Study Design: | Allocation: Non-Randomized Endpoint Classification: Pharmacokinetics/Dynamics Study Intervention Model: Single Group Assignment Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor) Primary Purpose: Diagnostic |
| Official Title: | The Effects of Marijuana on Orientation and Motor Coordination and Brain Metabolism in Regular Smokers of Marijuana. |
- Brain metabolic activity (FDG) [ Time Frame: 30-40 minutes ] [ Designated as safety issue: No ]
- Reaction time (RTs) and errors in performance [ Time Frame: 40 minutes ] [ Designated as safety issue: No ]
- Subjective ratings on visual analog scale [ Time Frame: 10 minutes ] [ Designated as safety issue: No ]
| Enrollment: | 12 |
| Study Start Date: | July 2004 |
| Study Completion Date: | December 2005 |
| Primary Completion Date: | December 2005 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Placebo Comparator: A
Low nicotine cigarettes without THC
|
Drug: Tetra Hydro Cannabinol (THC)
Oral THC 13mg and 17mg smoked in low nicotine cigarettes
Other Name: Marijuana, cannabis
|
Detailed Description:
This study investigates the effects of 17mg and 13mg Delta THC on orientation and motor coordination and brain metabolic activity in regular users of marijuana. Subjects were tested twice, after smoking cigarettes with marijuana and after smoking cigarettes without marijuana. On both occasions they performed on a virtual reality maze task. They were afterwards scanned in Positron Emission Tomography (PET) with Fluoro-deoxy-glucose (FDG). 12 subjects were tested so far on both conditions.
Eligibility| Ages Eligible for Study: | 20 Years to 65 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Marijuana dependence
- Age 20-65
- Male and female
Exclusion Criteria:
- Pregnant women
- Dependence on other substances
- Psychiatric diagnosis apart from marijuana dependence
- Neurological disorder
- Young persons
Contacts and Locations| Israel | |
| Department of Nuclear Medicine | |
| Tel Aviv, Israel, 64239 | |
| Principal Investigator: | Aviv M Weinstein, Ph.D | Sourasky Medical Center |
| Principal Investigator: | Einat Even-Sapir, M.D. Ph.D | Sourasky Medical Center |
More Information
No publications provided
| Responsible Party: | Dr. Michal Roll, Sourasky Medical Center Tel Aviv |
| ClinicalTrials.gov Identifier: | NCT00270803 History of Changes |
| Other Study ID Numbers: | TASMC-05-EE-03-124-CTIL |
| Study First Received: | December 25, 2005 |
| Last Updated: | May 6, 2008 |
| Health Authority: | Israel: Israeli Health Ministry Pharmaceutical Administration |
Keywords provided by Tel-Aviv Sourasky Medical Center:
|
Marijuana, FDG, PET, maze, THC, motor coordination. |
Additional relevant MeSH terms:
|
Marijuana Abuse Substance-Related Disorders Mental Disorders |
ClinicalTrials.gov processed this record on June 17, 2013