Hypertrophic Myopathy in Children
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Purpose
The purpose of this study is to identify the patients seen in our practice who are seen with Hypertrophic Myopathy diagnosis in order to better understand the presenting characteristics of their disease, the diagnostic testing to determine the diagnosis, the methods used to follow the disease progression and management practices used in caring for these patients. The objectives of this data review will be an analysis to determine if there is a methodology that will foster improved diagnostic speed and accuracy, and determine the best management practices based on outcomes in these patients.
| Condition |
|---|
|
Congenital Disorders |
| Study Type: | Observational |
| Study Design: | Observational Model: Defined Population Observational Model: Natural History Time Perspective: Longitudinal Time Perspective: Retrospective |
| Official Title: | Retrospective Review of Hypertrophic Myopathy in Children |
| Estimated Enrollment: | 75 |
| Study Start Date: | January 1996 |
The charts of children followed at Sibley Heart Center of Children's Healthcare of Atlanta will be identified using the Mysis system and screening for the appropriate ICD-9 codes for the types of Hypertrophic Myopathy. These codes include: 425.1, 425.4, 425.7, 425.8, and 425.9. Screening will also be done for known anomalies that are associated with hypertrophic myopathy as seen in some syndromes and metabolic disorders.
Data Collection:
Age at presentation (DOB) History – Prenatal, Family, Current Surgical Procedures Physical Exam results EKG interpretation CXR results Echocardiography results MRI Results Holter monitors results Exercise testing results Radionuclear study results Spiral CT Study results Genetics Testing results Medication usage Enzyme replacement therapy usage Diagnostic laboratory results
Statistics:
A generalized linear model will be performed. Significance will be defined at P≤ 0.05.
Interim monitoring of accumulated data will be performed. One interim analysis will be performed after 3 months of accrual with additional analyses being performed at the end of data collection.
Demographic data will be summarized for all subjects. For each patient summary statistics will include the mean, standard deviation, frequency distribution, minimum, maximum and range.
Eligibility| Ages Eligible for Study: | up to 21 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- seen at Sibley Heart Center, Children's Healthcare of Atlanta
- diagnosed with Hypertrophic Myopathy
Exclusion Criteria:
- those who do not meet inclusion criteria
Contacts and Locations| United States, Georgia | |
| Children's Healthcare of Atlanta | |
| Atlanta, Georgia, United States, 30322 | |
| Principal Investigator: | Kenneth J. Dooley, MD | Sibley Heart Center Cardiology at Children's Healthcare of Atlanta |
More Information
No publications provided
| ClinicalTrials.gov Identifier: | NCT00267462 History of Changes |
| Other Study ID Numbers: | 05-034 |
| Study First Received: | December 19, 2005 |
| Last Updated: | May 3, 2007 |
| Health Authority: | United States: Food and Drug Administration |
Keywords provided by Children's Healthcare of Atlanta:
|
pediatric cardiac hypertrophic Myopathy |
Additional relevant MeSH terms:
|
Hypertrophy Muscular Diseases Pathological Conditions, Anatomical |
Musculoskeletal Diseases Neuromuscular Diseases Nervous System Diseases |
ClinicalTrials.gov processed this record on May 16, 2013