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| Sponsor: | National Institute on Aging (NIA) |
|---|---|
| Collaborator: |
University of Kansas |
| Information provided by: | National Institute on Aging (NIA) |
| ClinicalTrials.gov Identifier: | NCT00267124 |
Purpose
The purpose of this study is to determine the effects of exercise and cardiorespiratory fitness on age-related brain changes.
| Condition |
|---|
|
Alzheimer's Disease |
| Study Type: | Observational |
| Study Design: | Case Control, Prospective |
| Official Title: | KU Brain Aging Project |
Blood samples are collected analyzed and banked as whole blood, serum, white blood cells
| Estimated Enrollment: | 120 |
| Study Start Date: | November 2004 |
| Estimated Study Completion Date: | December 2009 |
| Estimated Primary Completion Date: | December 2009 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
|
1
elderly people who have normal cognition
|
|
2
elderly people who have mild to moderate Alzheimer's disease
|
The mission of the KU Brain Aging Project is to promote healthy brain aging. How the brain changes with age is not well-characterized and even less is known about the factors influencing the rate of brain aging. Thus, we are using MRI scans to examine the structure of the brain in relation to important lifestyle factors. This will allow us to better understand the processes influencing the brain as it ages. In turn, this will help identify specific ways to promote healthy brain aging and, perhaps, prevent the onset of Alzheimer's disease.
Participants complete 4 visits over several months. The first visit entails a clinical evaluation and memory testing involving the use of paper and pencil testing. The second visit is an MRI brain scan which lasts approximately one hour. The third visit involves drawing blood for laboratory testing and blood banking for future lab studies, lasting roughly 4 hours. The glucose tolerance test is administered. The fourth and final visit is an assessment of the participant's metabolism and exercise testing. This visit lasts approximately two hours.
Eligibility| Ages Eligible for Study: | 65 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
KU memory clinic patients, volunteers from the community, and the states of Kansas and Missouri
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| United States, Kansas | |
| University of Kansas Medical Center | |
| Kansas City, Kansas, United States, 66160 | |
| Principal Investigator: | Jeffrey Burns, MD | University of Kansas Medical Center, Landon Center on Aging |
More Information
| Responsible Party: | University of Kansas Medical Center ( Jeffrey Burns, MD ) |
| Study ID Numbers: | IA0089, 1R03AG026374-01 |
| Study First Received: | December 16, 2005 |
| Last Updated: | April 28, 2009 |
| ClinicalTrials.gov Identifier: | NCT00267124 History of Changes |
| Health Authority: | United States: Federal Government |
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cognitive decline dementia neuroimaging |
|
Delirium, Dementia, Amnestic, Cognitive Disorders Mental Disorders Nervous System Diseases Alzheimer Disease Central Nervous System Diseases |
Neurodegenerative Diseases Tauopathies Brain Diseases Dementia |