Investigation of Genetic Risk of Cardiovascular Disease in Prospective Cohort Study

The recruitment status of this study is unknown because the information has not been verified recently.

Verified September 2007 by Nagoya University.
Recruitment status was Recruiting

Sponsor:

Collaborator:

Aichi Gakuin University

Information provided by:

Nagoya University

ClinicalTrials.gov Identifier:

NCT00262691

First received: December 6, 2005

Last updated: September 20, 2007

Last verified: September 2007

History of Changes

Purpose

Cardiovascular disease is a complex multifactorial and polygenic disorder that is thought to result from an interaction between a person's genetic make up and various environmental factors. Although many studies have revealed that several genetic variants increase the risk of cardiovascular disease, the results of these studies remain controversial. The purpose of this study is to identify polymorphisms that confer susceptibility to cardiovascular disease and to clarify the adequacy of reported susceptibility gene polymorphisms. To complete this purpose, we will prospectively study over 5,000 local residents in whom relationship between these polymorphisms and occurrence of cardiovascular disease over 5 years.

Condition
Healthy Coronary Disease Myocardial Infarction Cerebral Infarction

Study Type:	Observational
Study Design:	Observational Model: Case Control Observational Model: Natural History Time Perspective: Longitudinal Time Perspective: Prospective
Official Title:	Investigation of Genetic Risk of Cardiovascular Disease in Prospective Cohort Study, the Kitanagoya Genome (KING) Study for the Local Residents of Kitanagoya, Japan

Resource links provided by NLM:

MedlinePlus related topics: Coronary Artery Disease Heart Attack

U.S. FDA Resources

Further study details as provided by Nagoya University:

Estimated Enrollment:	7000
Study Start Date:	May 2005

Eligibility

Ages Eligible for Study:	50 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Healthy subjects who undergo community-based annual health check in Kitanagoya city

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00262691

Contacts

Contact: Mitsuhiro Yokota, MD, PhD	+81-52-759-2111 ext 369	myokota@dpc.aichi-gakuin.ac.jp
Contact: Mitsuhiro Yokota, MD, PhD	+81-52-744-5515	mitsuhiro.yokota@theranos-inst.com

Locations

Japan
Department of Genome Science, School of Dentistry, Aichi-Gakuin University	Recruiting
Nagoya, Aichi, Japan, 464-8651
Contact: Mitsuhiro Yokota, MD, PhD +81-52-759-2111 ext 369 myokota@dpc.aichi-gakuin.ac.jp
Principal Investigator: Mitsuhiro Yokota, MD, PhD

Sponsors and Collaborators

Nagoya University

Aichi Gakuin University

Investigators

Study Chair:

Mitsuhiro Yokota, MD, PhD

Department of Genome Science, School o Dentistry, Aichi-Gakuin University

More Information

No publications provided by Nagoya University

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Nakatochi M, Miyata S, Tanimura D, Izawa H, Asano H, Murase Y, Kato R, Ichihara S, Naruse K, Matsubara T, Honda H, Yokota M. The ratio of adiponectin to homeostasis model assessment of insulin resistance is a powerful index of each component of metabolic syndrome in an aged Japanese population: results from the KING Study. Diabetes Res Clin Pract. 2011 Jun;92(3):e61-5. Epub 2011 Mar 31.

Tanimura D, Shibata R, Izawa H, Hirashiki A, Asano H, Murase Y, Miyata S, Nakatochi M, Ouchi N, Ichihara S, Yasui K, Yoshida T, Naruse K, Matsubara T, Yokota M. Relation of a common variant of the adiponectin gene to serum adiponectin concentration and metabolic traits in an aged Japanese population. Eur J Hum Genet. 2011 Mar;19(3):262-9. Epub 2010 Dec 8.

Asano H, Izawa H, Nagata K, Nakatochi M, Kobayashi M, Hirashiki A, Shintani S, Nishizawa T, Tanimura D, Naruse K, Matsubara T, Murohara T, Yokota M. Plasma resistin concentration determined by common variants in the resistin gene and associated with metabolic traits in an aged Japanese population. Diabetologia. 2010 Feb;53(2):234-46. Epub 2009 Sep 1.

ClinicalTrials.gov Identifier:	NCT00262691 History of Changes
Other Study ID Numbers:	NU-05-G-0001
Study First Received:	December 6, 2005
Last Updated:	September 20, 2007
Health Authority:	Japan: Ministry of Health, Labor and Welfare

Additional relevant MeSH terms:

Cardiovascular Diseases
Cerebral Infarction
Stroke
Coronary Disease
Coronary Artery Disease
Infarction
Myocardial Infarction
Brain Infarction
Brain Ischemia
Cerebrovascular Disorders
Brain Diseases

Central Nervous System Diseases
Nervous System Diseases
Vascular Diseases
Myocardial Ischemia
Heart Diseases
Arteriosclerosis
Arterial Occlusive Diseases
Ischemia
Pathologic Processes
Necrosis

ClinicalTrials.gov processed this record on May 23, 2013

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