Genetics of Recurrent Early Onset Major Depression

The recruitment status of this study is unknown because the information has not been verified recently.
Verified May 2009 by National Institute of Mental Health (NIMH).
Recruitment status was  Active, not recruiting
Sponsor:
Information provided by:
National Institute of Mental Health (NIMH)
ClinicalTrials.gov Identifier:
NCT00260182
First received: November 28, 2005
Last updated: January 3, 2011
Last verified: May 2009
  Purpose

This study will identify specific genes that may cause a predisposition to depression in some families.


Condition
Depression

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Genetics of Recurrent Early Onset Major Depression

Further study details as provided by National Institute of Mental Health (NIMH):

Biospecimen Retention:   Samples With DNA

Blood samples with DNA


Estimated Enrollment: 1500
Study Start Date: October 2005
Estimated Study Completion Date: June 2009
Estimated Primary Completion Date: June 2009 (Final data collection date for primary outcome measure)
Detailed Description:

Depression is a serious medical illness that is often difficult to diagnose and treat. Studies on patterns of depression within families suggest that inherited genes may cause a predisposition to the disorder. People with early onset depression often have more relatives with depression than people whose depression does not begin until later in life. It is likely that several interacting genes cause this tendency towards the disorder, rather than one specific gene. This study will serve to identify particular genes that may cause a susceptibility to depression in order to better understand the brain mechanisms involved with severe depression. In turn, this may aid in the development of new treatments for depression.

Participation in this observational study will entail one interview and one blood test. Participants will be interviewed, either in person or by telephone, about their personal and family psychiatric history. The blood sample will be collected at a time and location that is convenient for the participant. Participants may also be asked to invite other family members to participate in the study.

For information on a related study please follow this link:

http://clinicaltrials.gov/show/NCT00005914

  Eligibility

Ages Eligible for Study:   21 Years to 70 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

The study will include participants with a family history of depression.

Criteria

Inclusion Criteria:

  • History of recurrent major depression
  • Has a parent or sibling with a history of recurrent major depression
  • Depression began before the age of 31

Exclusion Criteria:

  • Bipolar I (manic-depressive) disorder
  • Schizophrenia
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00260182

Locations
United States, California
Stanford University
Palo Alto, California, United States, 94304
United States, District of Columbia
Howard University
Washington, District of Columbia, United States, 20060
United States, Illinois
Rush University Medical Center
Chicago, Illinois, United States, 60612
United States, Iowa
University of Iowa
Iowa City, Iowa, United States, 52242
United States, Maryland
Johns Hopkins University
Baltimore, Maryland, United States, 21287
United States, New York
Columbia University/New York State Psychiatric Institute
New York, New York, United States, 10032
Sponsors and Collaborators
Investigators
Principal Investigator: Douglas F. Levinson, MD Stanford University
Principal Investigator: Myrna M. Weissman, PhD Columbia University/New York State Psychiatric Institute
Principal Investigator: J. Raymond DePaulo, MD Johns Hopkins University
Principal Investigator: William A. Scheftner, MD Rush University Medical Center
Principal Investigator: William Coryell, MD University of Iowa
Principal Investigator: William Lawson, MD Howard University
  More Information

Additional Information:
No publications provided

Responsible Party: GenRED Study, Stanford University
ClinicalTrials.gov Identifier: NCT00260182     History of Changes
Other Study ID Numbers: R01 MH061686-02, R01 MH059542, R01 MH059552, R01 MH075131, R01 MH059541, R01 MH060912, DNBBS 7G-GRR
Study First Received: November 28, 2005
Last Updated: January 3, 2011
Health Authority: United States: Federal Government

Keywords provided by National Institute of Mental Health (NIMH):
Depressive Disorder
Family
Genetics

Additional relevant MeSH terms:
Depression
Depressive Disorder
Depressive Disorder, Major
Behavioral Symptoms
Mood Disorders
Mental Disorders

ClinicalTrials.gov processed this record on September 30, 2014