Microvascular Reactivity.

This study has been completed.

First Received: November 28, 2005 Last Updated: October 5, 2006 History of Changes

Sponsor:	Yale University
Information provided by:	Yale University
ClinicalTrials.gov Identifier:	NCT00259701

Purpose

This study attempts to test capillary responses to various challenges without the need for iontophoresis (electrical current).

Condition	Intervention
Diabetes Retinopathy Vascular Pathology	Device: Laser Doppler Flowmetry with topical acetylcholine and nitroglycerin

Study Type:	Observational
Study Design:	Screening, Cross-Sectional, Defined Population, Prospective Study
Official Title:	Transdermal Application of Acetylcholine and Nitroglycerin Without Iontophoresis.

Resource links provided by NLM:

MedlinePlus related topics: Retinal Disorders

Drug Information available for: Acetylcholine Nitroglycerin Acetylcholine chloride

U.S. FDA Resources

Further study details as provided by Yale University:

Estimated Enrollment:	20
Study Start Date:	June 2005
Estimated Study Completion Date:	September 2005

Detailed Description:

Studies of microvascular responsiveness often employ iontophoresis to fascilitate drug absorption. Iontophoresis is a confounding stimulus in such studies, and we are attempting to create tests of the microvasculature that do not require iontophoretic drug delivery.

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria: diabetic. -

Exclusion Criteria: not on nitrates or mydriatic eye drops within 48 hours.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00259701

Locations

United States, Connecticut
Yale School of Medicine
New HAven, Connecticut, United States, 06510

Sponsors and Collaborators

Yale University

Investigators

Principal Investigator:

David G Silverman

Yale School of Medicine

More Information

No publications provided by Yale University

Additional publications automatically indexed to this study by National Clinical Trials Identifier (NCT ID):

Schonberger RB, Worden WS, Shahmohammadi K, Menn K, Silverman TJ, Stout RG, Shelley KH, Silverman DG. Topical non-iontophoretic application of acetylcholine and nitroglycerin via a translucent patch: a new means for assessing microvascular reactivity. Yale J Biol Med. 2006 Mar;79(1):1-7.

Study ID Numbers:	HIC-12397-1
Study First Received:	November 28, 2005
Last Updated:	October 5, 2006
ClinicalTrials.gov Identifier:	NCT00259701 History of Changes
Health Authority:	United States: Institutional Review Board

Keywords provided by Yale University:

endothelium
iontophoresis
acetylcholine
nitroglycerin
vasodilation

Additional relevant MeSH terms:

Nitroglycerin
Vasodilator Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Therapeutic Uses
Eye Diseases

Physiological Effects of Drugs
Acetylcholine
Cardiovascular Agents
Cholinergic Agents
Pharmacologic Actions
Retinal Diseases

ClinicalTrials.gov processed this record on November 27, 2009