Calcium Channel Splice Variant Expression in Cardiovascular Disease and Aging - Full Text View

Purpose

The purpose of this study is to learn what changes in blood vessel contraction may occur as a result of a disease of the vessel that requires surgery. The study will examine the calcium channels present in the vessels being operated on, and the genes that may alter blood vessel function. Possible variation in these genes may change the kind of calcium channels present in blood vessels.

Condition

Atherosclerosis

Genetics Home Reference related topics:

Vascular Diseases

MedlinePlus related topics:

Vascular Diseases

ChemIDplus related topics:

Calcium gluconate

U.S. FDA Resources

Study Type:	Observational
Study Design:	Natural History

Official Title:	Calcium Channel Splice Variant Expression in Cardiovascular Disease and Aging

Further study details as provided by National Institute on Aging (NIA):

Estimated Enrollment:	500
Study Start Date:	February 2003
Estimated Study Completion Date:	August 2006

Detailed Description:

The goal of this study is to learn more about how blood vessels function and the mechanism that causes them to contract. The study will investigate the natural history of diseased blood vessel tissue and the calcium channels in the muscle part of the blood vessel. The study will also examine how genetics influences cardiovascular disease and its causes and treatments.

Patients scheduled for vascular surgery will be approached to participate in this study. During surgery, tissue fragments of diseased and marginal tissue will be obtained. A blood sample will be obtained at either the time of surgery or consent and genomic DNA will be extracted.

Eligibility

Ages Eligible for Study:	21 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Ages 21 and older
Scheduled for vascular surgery

Exclusion Criteria:

Unwillingness to be subjected to diagnostic and/or therapeutic procedures that are deemed not necessary for clinical management
Volunteers deemed too fragile to participate in the study by the principal investigator (PI) or the attending physician
Inability to obtain informed consent from either the volunteer or the responsible party (durable power of attorney [DPA]) for the volunteer, with the volunteer’s assent

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00251615

Contacts


Contact: Darrell R. Abernethy, MD, PhD	410-558-8626	abernethyd@grc.nia.nih.gov

Locations


United States, Maryland
	National Institute on Aging, Harbor Hospital	Recruiting
	Baltimore, Maryland, United States, 21225
	Contact: Kristen Gowan, RN 410-350-7374 gowank@grc.nia.nih.gov

Sponsors and Collaborators

National Institute on Aging (NIA)

Investigators


Principal Investigator:	Darrell R. Abernethy, MD, PhD	National Institute on Aging, Laboratory of Clinical Investigation

More Information

Publications:

Harry JB, Kobrinsky E, Abernethy DR, Soldatov NM. New short splice variants of the human cardiac Cavbeta2 subunit: redefining the major functional motifs implemented in modulation of the Cav1.2 channel. J Biol Chem. 2004 Nov 5;279(45):46367-72. Epub 2004 Aug 31.

Kobrinsky E, Tiwari S, Maltsev VA, Harry JB, Lakatta E, Abernethy DR, Soldatov NM. Differential role of the alpha1C subunit tails in regulation of the Cav1.2 channel by membrane potential, beta subunits, and Ca2+ ions. J Biol Chem. 2005 Apr 1;280(13):12474-85. Epub 2005 Jan 25.

Abernethy DR, Soldatov NM. Structure-functional diversity of human L-type Ca2+ channel: perspectives for new pharmacological targets. J Pharmacol Exp Ther. 2002 Mar;300(3):724-8. Review.

Study ID Numbers:	AG0058
First Received:	November 8, 2005
Last Updated:	July 20, 2007
ClinicalTrials.gov Identifier:	NCT00251615
Health Authority:	United States: Federal Government

Keywords provided by National Institute on Aging (NIA):

vascular surgery

vascular aging

arterial aging

surgical tissue

Aging

Study placed in the following topic categories:

Arterial Occlusive Diseases

Atherosclerosis

Vascular Diseases

Arteriosclerosis

Additional relevant MeSH terms:

Cardiovascular Diseases

ClinicalTrials.gov processed this record on May 11, 2008

Sponsored by:	National Institute on Aging (NIA)
Information provided by:	National Institute on Aging (NIA)
ClinicalTrials.gov Identifier:	NCT00251615