Study of Follicle Stimulating Hormone (FSH) Receptor in Women With Low Antral Follicle Count

This study has been completed.
Sponsor:
Information provided by:
Assistance Publique - Hôpitaux de Paris
ClinicalTrials.gov Identifier:
NCT00231504
First received: October 3, 2005
Last updated: January 5, 2010
Last verified: March 2007
  Purpose

The deficit in the total number of antral follicles is associated with a reduction of the ovarian fertility potential in young women.

The principal objective of this study is to evaluate the relationship between FSH receptor polymorphism and antral follicle count.

The investigators have designed a study of FSH receptor polymorphisms P1 and P2 as an association with a low antral follicle count in the ovary.


Condition Intervention Phase
Antral Follicle Deficit
Fertility
Procedure: Blood samples
Phase 1

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Study of Follicle Stimulating Hormone (FSH) Receptor in Women With Low Antral Follicle Count

Further study details as provided by Assistance Publique - Hôpitaux de Paris:

Biospecimen Retention:   Samples With DNA

DNA


Enrollment: 82
Study Start Date: October 2005
Study Completion Date: May 2009
Primary Completion Date: March 2009 (Final data collection date for primary outcome measure)
Intervention Details:
    Procedure: Blood samples
    Blood samples
    Other Name: Blood samples
Detailed Description:

The present study will compare the prevalence of FSH receptor polymorphisms P1 and P2 in women having reduced follicle count (1 to 9 antral follicles) or normal follicle count (13 to 20 antral follicles) determined by ultrasound scans.

  Eligibility

Ages Eligible for Study:   18 Years to 35 Years
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

YOUNG WOMAN

Criteria

Inclusion Criteria:

  • 18 to 35 years old
  • 1 to 9 or 13 to 20 antral follicles
  • Caucasian, occidental Europe
  • Presence of both ovaries
  • Informed consent

Exclusion Criteria:

  • Ovarian anomalies
  • Menopause
  • Pregnancy
  • Other diseases
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00231504

Locations
France
Antoine Beclere Hospital, Obstetrics and Gynaecology and Reproduction Medicine Service
Paris, France, 92140
Sponsors and Collaborators
Assistance Publique - Hôpitaux de Paris
Investigators
Principal Investigator: Renato FANCHIN, MD Assistance Publique - Hôpitaux de Paris
  More Information

No publications provided

Responsible Party: Christophe Aucan, Department Clinical Rechearch of Developpement
ClinicalTrials.gov Identifier: NCT00231504     History of Changes
Other Study ID Numbers: P041013, CRC04140
Study First Received: October 3, 2005
Last Updated: January 5, 2010
Health Authority: France: Ministry of Health

Keywords provided by Assistance Publique - Hôpitaux de Paris:
Polymorphism P1
Polymorphism P2
FSH Receptor
Antral follicle count
FSH receptor polymorphism

Additional relevant MeSH terms:
Follicle Stimulating Hormone
Hormones
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs
Pharmacologic Actions

ClinicalTrials.gov processed this record on August 18, 2014