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| Sponsored by: |
Rockefeller University |
| Information provided by: | Rockefeller University |
| ClinicalTrials.gov Identifier: | NCT00229255 |
Purpose
The purpose of this study is to test the relationship between frequency of meals and hepatic fat content and insulin sensitivity. We, the researchers at Rockefeller University, hypothesize that low plasma insulin levels (as achieved by periods of fasting) will prevent insulin resistance and reduce hepatic lipid content. In contrast, frequent, carbohydrate-rich meals will predispose to hepatic steatosis (non-alcoholic) and insulin resistance.
This is a 6 week inpatient study.
| Condition | Intervention |
|
Obesity Insulin Resistance Fatty Liver |
Behavioral: Frequency of meals |
| MedlinePlus related topics: | Obesity |
| Study Type: | Interventional |
| Study Design: | Prevention, Randomized, Open Label, Active Control, Parallel Assignment |
| Official Title: | Relation of Obesity With Frequency of Meals (MST 0557) |
| Estimated Enrollment: | 50 |
| Study Start Date: | March 2005 |
The hypothesis will be tested by studying two groups of normal subjects who will receive a defined weight maintenance diet: one group will be given meals twice a day and other group will be given eight meals (snacks) per day. At the beginning of the study period and after 4 weeks following the specified frequency of meals, the study subjects will have their whole body insulin sensitivity and hepatic fat content measured by the euglycemic-hyperinsulinemic clamp and MRI of the liver, respectively.
Eligibility
| Ages Eligible for Study: | 18 Years to 45 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| United States, New York | |||||
| Rockefeller University Hospital | |||||
| New York, New York, United States, 10021 | |||||
| Rockefeller University |
| Principal Investigator: | Markus Stoffel, MD, PHD | Rockefeller University |
More Information
Related Info 
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| Study ID Numbers: | MST-0557 |
| First Received: | September 27, 2005 |
| Last Updated: | July 3, 2008 |
| ClinicalTrials.gov Identifier: | NCT00229255 |
| Health Authority: | United States: Institutional Review Board |
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