ClinicalTrials.gov processed this data on March 28, 2024Link to the current ClinicalTrials.gov record.https://clinicaltrials.gov/ct2/show/NCT00223548A119/2002NCT00223548MESNA for Prevention of Acute Deterioration of Renal Function Following Contrast Agent ApplicationMESNA Zur Prophylaxe Der Kontrastmittel-Induzierten NephropathieUniversity of UlmOther
The purpose of this study is to determine wether Mesna could prevent contrast-induced
nephropathy
Contrast-induced nephropathy remains a common complication of radiographic precedures.
Pretreatment with Mesna (Sodium 2-mercaptoethane sulfonate) in combination with sodium
chloride is more protective than sodium chloride alone in animal models of acute renal
failure.
The aim of this study is therefore to determine laboratory and clinical benefit of MESNA, as
an adjunct to saline hydration, in patients with known renal impairment receiving contrast
media.
CompletedOctober 2002December 2004Phase 2InterventionalNoRandomizedParallel AssignmentPreventionDoubleContrast-agent associated nephrotoxicity was defined as an increase in serum creatinine concentration >0.5 mg/dl (44 umol/l) of the baseline value 48 h after administration of the contrast media.Need for dialysis after the administration of contrast media.106Chronic Renal InsufficiencySerum Creatinine ConcentrationContrast Media ExpositionDrugsodium 2-mercaptoethane sulfonate
Inclusion Criteria:
- stable chronic renal insufficiency
- serum creatinine concentration > 1,5 mg/dl
Exclusion Criteria:
- Dialyzed patients
- patients with acute renal failure
- received iodinated contrast media within 7 days before study entry
- known allery to Mesna, pregnancy, and administration of dopamine, mannitol or
N-acetylcysteine
All18 YearsN/ANoFrieder Keller, M.D.Principal InvestigatorDivision of Nephrology, University Hospital UlmFrieder Keller, M.D.Principal InvestigatorDivision of Nephrology, University Hospital of UlmDivision of Nephrology, University of UlmUlm89081GermanyGermanySeptember 2002September 14, 2005September 14, 2005September 22, 2005September 14, 2005September 14, 2005September 22, 2005prophylaxiscontrast-induced nephropathymesnaacute renal failureRenal InsufficiencyRenal Insufficiency, ChronicMesna