Randomized Controlled Trial of Doxycycline to Prevent Acquisition of Mycoplasma Pneumoniae in an Outbreak Setting

This study has been completed.

First Received: September 13, 2005 No Changes Posted

Sponsored by:	Centers for Disease Control and Prevention
Information provided by:	Centers for Disease Control and Prevention
ClinicalTrials.gov Identifier:	NCT00207584

Purpose

This study was designed to determine whether taking daily doxycycline during an outbreak of Mycoplasma pneumoniae could prevent a person from getting infected and interrupt ongoing disease transmission during an outbreak. Doxycycline is a treatment for Mycoplasma pneumoniae, but it is not certain that the drug could prevent disease if used prophylactically.

Condition	Intervention
Mycoplasma Pneumoniae	Drug: Doxycycline treatment

Study Type:	Interventional
Study Design:	Randomized, Double-Blind, Placebo Control, Parallel Assignment
Official Title:	A Double-Blind, Randomized Placebo-Controlled Trial of Doxycycline for Chemoprophylaxis in the Setting of an Outbreak of Mycoplasma Pneumoniae

Resource links provided by NLM:

MedlinePlus related topics: Pneumonia

Drug Information available for: Doxycycline Doxycycline hyclate Doxycycline calcium

U.S. FDA Resources

Further study details as provided by Centers for Disease Control and Prevention:

Study Start Date:	January 1994
Estimated Study Completion Date:	April 1994

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Working at hospital facility where outbreak of Mycoplasma pneumoniae occured

Exclusion Criteria:

Pregnant, on antiseizure medications, allergic to macrolide antibiotics

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00207584

Sponsors and Collaborators

Centers for Disease Control and Prevention

Investigators

Principal Investigator:

Julia A Schillinger, MD

Centers for Disease Control and Prevention

More Information

No publications provided

Study ID Numbers:	CDC-NCHSTP-9997
Study First Received:	September 13, 2005
Last Updated:	September 13, 2005
ClinicalTrials.gov Identifier:	NCT00207584 History of Changes
Health Authority:	United States: Federal Government

Study placed in the following topic categories:

Bacterial Infections
Pneumonia, Mycoplasma
Pleurisy
Pleural Diseases
Mycoplasma Infections
Pleuropneumonia
Gram-Negative Bacterial Infections
Antimalarials

Anti-Bacterial Agents
Respiratory Tract Diseases
Respiratory Tract Infections
Lung Diseases
Pneumonia, Bacterial
Mycoplasmal Pneumonia
Doxycycline
Pneumonia

Additional relevant MeSH terms:

Bacterial Infections
Anti-Infective Agents
Antiprotozoal Agents
Pneumonia, Mycoplasma
Pleurisy
Pleural Diseases
Mycoplasma Infections
Pharmacologic Actions
Pleuropneumonia
Gram-Negative Bacterial Infections
Mycoplasmatales Infections

Antimalarials
Anti-Bacterial Agents
Antiparasitic Agents
Respiratory Tract Diseases
Respiratory Tract Infections
Therapeutic Uses
Lung Diseases
Pneumonia, Bacterial
Doxycycline
Pneumonia

ClinicalTrials.gov processed this record on July 02, 2009