The Role of Reactive Oxygen Species in Ischaemia-Reperfusion Injury of the Transplanted Kidney

The recruitment status of this study is unknown because the information has not been verified recently.
Verified August 2005 by Uniwersytet Mikolaja Kopernika w Toruniu.
Recruitment status was  Active, not recruiting
Sponsor:
Information provided by:
Uniwersytet Mikolaja Kopernika w Toruniu
ClinicalTrials.gov Identifier:
NCT00204178
First received: September 13, 2005
Last updated: November 30, 2005
Last verified: August 2005
  Purpose

Measurement of reactive oxygen species production and antioxidant system status before and directly after reperfusion of the transplanted kidney and influence of oxidant stress on kidney function in 2 and 6 weeks.


Condition Intervention
Kidney Transplantation
Behavioral: Oxidative stress in kidney transplant recipients

Study Type: Observational
Study Design: Observational Model: Defined Population
Time Perspective: Cross-Sectional
Official Title: The Role of Reactive Oxygen Species in Ischaemia-Reperfusion Injury of the Transplanted Kidney

Resource links provided by NLM:


Further study details as provided by Uniwersytet Mikolaja Kopernika w Toruniu:

Estimated Enrollment: 60
Study Start Date: April 2003
Estimated Study Completion Date: September 2005
Detailed Description:

Oxidative stress is one of the most important factors in ischaemia-reperfusion injury to the transplanted organ. In kidney transplant recipients following factors were measured: glutathione level, activities of glutathione peroxidase (GSH-PX), catalase (CAT) and superoxide dismutase (SOD) and superoxide anion production by granulocytes in whole blood without and after the stimulation with zymosan.

Blood was sampled from peripheral vein (before reperfusion) and directly from renal vein (5 and 15 minutes after reperfusion).

Transplanted kidney function was evaluated by the incidence and length of Delayed Graft Function and serum creatinine level in 2 and 6 weeks after transplantation.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • consecutive patients accepted for and undergoing cadaveric kidney transplantation

Exclusion Criteria:

  • no informed consent
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00204178

Locations
Poland
Klinika Transplantologii, Szpital Uniwersytecki, ul. M. Sklodowskiej-Curie 9
Bydgoszcz, Poland, 85-094
Sponsors and Collaborators
Uniwersytet Mikolaja Kopernika w Toruniu
Investigators
Study Director: Zbigniew Wlodarczyk, MD,PhD Klinika Transplantologii Collegium Medicum UMK w Toruniu
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00204178     History of Changes
Other Study ID Numbers: KB/38/2003
Study First Received: September 13, 2005
Last Updated: November 30, 2005
Health Authority: Poland: Ministry of Health

Keywords provided by Uniwersytet Mikolaja Kopernika w Toruniu:
Kidney transplantation
Reperfusion injury

Additional relevant MeSH terms:
Ischemia
Reperfusion Injury
Wounds and Injuries
Pathologic Processes
Vascular Diseases
Cardiovascular Diseases
Postoperative Complications

ClinicalTrials.gov processed this record on July 28, 2014