Enrichment & Purging of Stem Cells in Non-Hodgkin's Lymphoma

This study has been completed.
Sponsor:
Collaborator:
Information provided by (Responsible Party):
Stanford University
ClinicalTrials.gov Identifier:
NCT00186355
First received: September 13, 2005
Last updated: May 10, 2012
Last verified: May 2012
  Purpose

To evaluate the role of purging the hematopoietic cell graft on outcomes for non-Hodgkin's Lymphoma.


Condition Intervention
Lymphoma, Non-Hodgkin
Procedure: high dose chemo then auto hematopoietic cell transplant

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Enrichment and Purging of Stem Cells in the Treatment of Non-Hodgkin's Lymphoma

Resource links provided by NLM:


Further study details as provided by Stanford University:

Primary Outcome Measures:
  • PCR positivity in peripheral blood cell collections after cyclophosphamide [ Time Frame: unknown ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Enrichment of hematopoietic stem cells [ Time Frame: unknown ] [ Designated as safety issue: No ]

Enrollment: 97
Study Start Date: October 2003
Study Completion Date: February 2010
Primary Completion Date: March 2007 (Final data collection date for primary outcome measure)
Detailed Description:

To study the use of peripheral blood stem cells which have been treated in an effort to remove tumor cells. The researchers hope to learn whether or not this will be more effective in removing the tumor cells as compared to other methods of purging (the removal of cancer cells).

  Eligibility

Ages Eligible for Study:   up to 75 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:- relapsed NHL

Exclusion Criteria:- liver dysfunction

  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00186355

Locations
United States, California
Stanford University School of Medicine
Stanford, California, United States, 94305
Sponsors and Collaborators
Stanford University
Investigators
Principal Investigator: Robert S Negrin Stanford University
  More Information

No publications provided

Responsible Party: Stanford University
ClinicalTrials.gov Identifier: NCT00186355     History of Changes
Other Study ID Numbers: BMT4IJ, 77063, 12170
Study First Received: September 13, 2005
Last Updated: May 10, 2012
Health Authority: United States: Institutional Review Board

Additional relevant MeSH terms:
Lymphoma
Lymphoma, Non-Hodgkin
Neoplasms by Histologic Type
Neoplasms
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases

ClinicalTrials.gov processed this record on August 27, 2014