The Effect of Caffeine on Ischemic Preconditioning
Ischaemic preconditioning (IP) describes the phenomenon that brief periods of ischaemia render the (myocardial) muscle more resistant to a subsequent more prolonged period of ischaemia and reperfusion. Animal studies have provided evidence that adenosine receptor stimulation is an important mediator of IP. As caffeine is an effective adenosine receptor antagonist already at concentrations reached after regular coffee consumption, we aimed to assess whether caffeine impairs IP in humans in vivo. We used a novel and well-validated model to study IP in humans: 99m-Tc-annexin A5 scintigraphy in forearm skeletal muscle.
24 healthy volunteers were randomly assigned to either caffeine (4 mg/kg/iv in 10 minutes) or saline before a protocol for IP.
Drug: Technetium-TC99m-labeled Annexin A5
Procedure: ten minutes forearm ischemia
Procedure: ischemic forearm exercise
|Study Design:||Allocation: Randomized
Intervention Model: Parallel Assignment
|Official Title:||Caffeine Reduces Acute Ischemic Preconditioning|
|Radboud University Nijmegen Medical Centre / Department of Pharmacology and Toxicology|
|Nijmegen, Gelderland, Netherlands, 6500 HB|
|Principal Investigator:||Gerard Rongen, MD, Phd||Radboud University Nijmegen Medical Centre / Department of pharmacology and Toxicology|