Collection of Bone Marrow Aspirate From Volunteer Donors - Full Text View

Sponsor:	National Institute on Aging (NIA)
Information provided by:	National Institute on Aging (NIA)
ClinicalTrials.gov Identifier:	NCT00183066

Purpose

The purpose of this study is to collect bone marrow cells for research purposes.

Condition
Aging

Study Type:	Observational
Study Design:	Prospective
Official Title:	Collection of Bone Marrow Aspirate From Volunteer Donors for In Vitro Hematopoietic Research

Further study details as provided by National Institute on Aging (NIA):

Biospecimen Retention: Samples With DNA

Biospecimen Description:

Bone marrow aspirates Whole blood

Estimated Enrollment:	50
Study Start Date:	July 2002
Estimated Study Completion Date:	December 2012
Estimated Primary Completion Date:	December 2012 (Final data collection date for primary outcome measure)

Detailed Description:

This study is designed to provide bone marrow cells for other research studies. The research is being done because there are ongoing experiments in a number of National Institute on Aging (NIA) laboratories that require access to normal human bone marrow aspirate for their studies of the immune system. These studies are done to understand how blood cells are formed and how they function. Samples will be used to study problems such as the immune system in bone marrow failure and related conditions. Cells will be used in laboratory research and may be banked for future laboratory studies

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes
Sampling Method:	Non-Probability Sample

Study Population

Healthy males and females 18 years and older

Criteria

Inclusion Criteria:

Healthy volunteers age 18 and over

Exclusion Criteria:

Significant abnormalities on health history questionnaire or in the results of blood tests
Pregnant or nursing mother
Participation in another research study within the past six weeks that is felt by the Principal Investigator to be incompatible with this study
Severe infection in the past two months
Immune disorder, or use of any medication that can alter immune system function
A medical or mental health finding showing inability to go through the procedure
Body mass index (BMI) greater than 29%
Chronic back pain, sciatica, or a compression fracture of the spine
Positive test results for viral infections: Hepatitis B, Hepatitis C, or HIV (AIDS)

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00183066

Contacts

Contact: Karen Madara, RN	410-350-3929	madarak@grc.nia.nih.gov
Contact: NIA Recruiter	410-350-3941

Locations

United States, Maryland
National Institute on Aging	Recruiting
Baltimore, Maryland, United States, 21225
Contact: Karen Madara, RN 410-350-3929 madarak@grc.nia.nih.gov
Principal Investigator: Dan L. Longo, MD

Sponsors and Collaborators

National Institute on Aging (NIA)

Investigators

Principal Investigator:

Dan L. Longo, MD

National Institute on Aging (NIA)

More Information

Additional Information:

National Institute on Aging This link exits the ClinicalTrials.gov site

Publications:

Cashman J, Clark-Lewis I, Eaves A, Eaves C. Stromal-derived factor 1 inhibits the cycling of very primitive human hematopoietic cells in vitro and in NOD/SCID mice. Blood. 2002 Feb 1;99(3):792-9.

Exley MA, Tahir SM, Cheng O, Shaulov A, Joyce R, Avigan D, Sackstein R, Balk SP. A major fraction of human bone marrow lymphocytes are Th2-like CD1d-reactive T cells that can suppress mixed lymphocyte responses. J Immunol. 2001 Nov 15;167(10):5531-4.

Johnson BS, Mueller L, Si J, Collins SJ. The cytokines IL-3 and GM-CSF regulate the transcriptional activity of retinoic acid receptors in different in vitro models of myeloid differentiation. Blood. 2002 Feb 1;99(3):746-53.

Responsible Party:	National Institute on Aging ( Dan L. Longo, MD )
Study ID Numbers:	AG0046
Study First Received:	September 13, 2005
Last Updated:	December 17, 2009
ClinicalTrials.gov Identifier:	NCT00183066 History of Changes
Health Authority:	United States: Federal Government

ClinicalTrials.gov processed this record on February 08, 2010