IL-7 Receptor Polymorphisms and Immune Recovery With HAART
The aim is to investigate the hypothesis that IL7-receptor polymorphisms contribute to the differential immune recovery of CD4 + T cells following HAART
|Study Design:||Observational Model: Cohort
Time Perspective: Retrospective
|Official Title:||The Relationship of Single Nucleotide Polymorphisms in the Interleukin-7 Receptor-α Gene to CD4+ Immune Recovery in HIV Infected Patients Who Begin Antiretroviral Treatment With HAART|
Plasma, PBMC and DNA
|Study Start Date:||May 2005|
|Study Completion Date:||May 2009|
AIM: To examine the association between the four haplotypes of IL-7Rα gene and a cohort of HIV infected patients who have commenced HAART with varying CD4+ T lymphocyte responses.
METHODS: IL-7Rα gene SNPs and haplotypes will be measured by constructing DNA pools, and PCR amplification and DNA sequencing. IL-7Rα expression will be examined using constitutive expression of IL-7Rα, IL-7Rα gene expression, and inducible expression of IL7Rα.
|The Alfred Hospital, Commercial Road|
|Melbourne, Victoria, Australia, 3004|
|Study Director:||Jennifer Hoy, A/Prof||The Alfred Hospital|
|Principal Investigator:||Sharon Lewin, Professor||Alfred Hospital, Melbourne, Vic 3004|