Cellular Immune Responses to Hepatitis B Virus (HBV)- Longitudinal Follow up and Natural History
It remains unclear why some individuals are able to clear HBV from their bodies while in others HBV is a persistent infection. We plan to investigate this process by collecting blood and analysing how the patient's white blood cells respond to different pieces of the HBV virus. We will use new tools that can precisely tell us which component of the immune response may be different in individuals who are chronically infected with HBV and also in individuals who are also infected with HIV.
The primary aims are therefore:
- To characterize HBV-specific T cell responses in HBV chronic carriers, and identify novel immunogenic regions in both HLA-A2+ and non-HLA-A2+ individuals.
- To determine the effect of HIV infection on HBV-specific T-cell responses
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Cellular Immune Responses to Hepatitis B Virus (HBV)- Longitudinal Follow up and Natural History|
|The Alfred Hospital, Commercial Road|
|Melbourne, Victoria, Australia, 3004|
|Principal Investigator:||Sharon Lewin, Professor||Burnet Institute, Melbourne|