Treatment of Melasma With Jessner's Solution vs. Trichloroacetic Acid

This study is ongoing, but not recruiting participants.

First Received: September 13, 2005 Last Updated: October 8, 2009 History of Changes

Sponsor:	Emory University
Information provided by:	Emory University
ClinicalTrials.gov Identifier:	NCT00166192

Purpose

Melasma is an acquired discoloration of the skin characterized by brown patches. Chemical peels using agents such as Jessner's solution and trichloroacetic acid (TCA) are commonly used to treat melasma. A chemical peel involves applying the peeling agent to the skin for a short period. The skin will peel similar to a sunburn, and moisturizers are applied to the skin. Although both agents are well-accepted, there have been no good comparisons of the two agents. The purpose of this study is determine if there is a difference in the effectiveness of these two agents.

Condition	Intervention	Phase
Melasma	Procedure: Jessner's solution chemical peel Procedure: Trichloroacetic acid chemical peel	Phase IV

Study Type:	Interventional
Study Design:	Treatment, Non-Randomized, Open Label, Active Control, Single Group Assignment, Efficacy Study
Official Title:	Treatment of Melasma With Jessner's Solution vs. Trichloroacetic Acid: A Comparison of Clinical Efficacy

Resource links provided by NLM:

Drug Information available for: Trichloroacetic acid

U.S. FDA Resources

Further study details as provided by Emory University:

Primary Outcome Measures:

Clinical efficacy by clinician's evaluation

Secondary Outcome Measures:

Efficacy by subject's evaluation

Estimated Enrollment:	113
Study Start Date:	January 2004

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Adults > 18 years old
Clinical diagnosis of melasma
Mental capacity to give informed consent

Exclusion Criteria:

Pregnancy
H/o allergy to Jessner's solution, tricholoracetetic acid, tretinoin, or hydroquinone
Active dermatitis
Presence of cutaneous infection

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00166192

Locations

United States, Georgia
Emory University Dermatology Clinic
Atlanta, Georgia, United States, 30322

Sponsors and Collaborators

Emory University

Investigators

Principal Investigator:

Carl Washington, MD

Emory University Department of Dermatology

More Information

No publications provided

Study ID Numbers:	904-2003
Study First Received:	September 13, 2005
Last Updated:	October 8, 2009
ClinicalTrials.gov Identifier:	NCT00166192 History of Changes
Health Authority:	United States: Food and Drug Administration

Keywords provided by Emory University:

Melasma
Jessner's solution
Trichloroacetic acid (TCA)

Additional relevant MeSH terms:

Anti-Infective Agents
Anti-Infective Agents, Local
Hyperpigmentation
Skin Diseases
Therapeutic Uses
Pigmentation Disorders

Physiological Effects of Drugs
Central Nervous System Depressants
Melanosis
Central Nervous System Agents
Pharmacologic Actions
Ethanol

ClinicalTrials.gov processed this record on November 09, 2009