Vasoreactivity in Carriers of Genetic Polymorphisms
Recruitment status was Recruiting
The objective of the study is to assess the impact of genetic variation (especially polymorphisms of the gene coding endothelial nitric oxide synthase (eNOS) and the bradykinin B2 receptor gene) on venous and arterial responsiveness to vasodilators in healthy individuals without cardiovascular risk factors.
|Study Design:||Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Primary Purpose: Educational/Counseling/Training
|Official Title:||Endothelium-Dependent Vasoreactivity in Nitric Oxide Synthase Gene (Glu298Asp) Polymorphism: Studies in Healthy Volunteers|
- Study I: Venous responsiveness assessed by dorsal hand vein compliance technique
- Study II: Forearm blood flow assessed by venous occlusion plethysmography
|Study Start Date:||November 1999|
|Estimated Study Completion Date:||December 2006|
Study I: Using the dorsal hand vein compliance technique dose-response curves to bradykinin and sodium nitroprusside will be obtained in healthy volunteers during preconstriction with phenylephrine and after pretreatment with a single dose of 500 mg i.v. acetylsalicylic acid.
Study II: Using venous occlusion plethysmography dose-response curves to acetylcholine, sodium nitroprusside and L-NG-monomethyl-arginine (L-NMMA) will be obtained in healthy volunteers pretreated with a single dose of 500mg i.v. acetylsalicylic acid.
|Contact: Walter E Haefeli, MD||+49-6221-56- ext 8740||Walter_Emil_Haefeli@med.uni-heidelberg.de|
|Dept. of Internal Medicine VI||Recruiting|
|Heidelberg, Baden-Württemberg, Germany, 69120|
|Principal Investigator:||Walter E Haefeli, MD||Dept. of Internal Medicine VI, University of Heidelberg|