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Analysis of Genetic Factors Which May Influence the Course of HIV Infection

This study has been completed.
Sponsor:
Information provided by:
Hadassah Medical Organization
ClinicalTrials.gov Identifier:
NCT00159068
First received: September 9, 2005
Last updated: June 22, 2011
Last verified: June 2010
History of Changes
  Purpose

Patients with HIV an have a variable course of their infection. We are trying to identify factors which worsen or ameliorate the course of the disease. Such factors may be related to metabolism (breakdown) of drugs or to iron handling by the body.


Condition
HIV Infection

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Genetic Influences on the Course and Response to Treatment of HIV: Contribution of Polymorphisms in Drug Metabolism and Disposition Genes and Haptoglobin Polymorphisms

Resource links provided by NLM:

MedlinePlus related topics: HIV/AIDS
U.S. FDA Resources

Further study details as provided by Hadassah Medical Organization:

Biospecimen Retention:   Samples With DNA

DNA isolated from peripheral blood.


Estimated Enrollment: 150
Study Start Date: February 2004
Study Completion Date: April 2011
Primary Completion Date: April 2011 (Final data collection date for primary outcome measure)
Detailed Description:

Patients with HIV can have a variable course and the disease may be influenced by polymorphisms in drug metabolism and disposition genes such as MDR1 and CYP3A4. In addition, reports have linked changes in the course of the disease with iron status, with high iron being detrimental. We will study polymorphisms in these genes and correlate with clinical course in HIV patients and also with phenotype of drug resistance and disease parameters (such as CD4 counts and opportunistic infections).

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Patients with HIV attending the HIV clinic at Hadassah colden globes.

Criteria

Inclusion Criteria:

  • diagnosis of HIV

Exclusion Criteria:

  • under 18 years of age
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00159068

Locations
Israel
Hadassah Medical Organization
Jerusalem, Israel, IL91120
Sponsors and Collaborators
Hadassah Medical Organization
Investigators
Principal Investigator: Deborah Rund, MD Hadassah Medical Organization
  More Information

Publications:

Responsible Party: Deborah Rund, Hadassah Medical Organization
ClinicalTrials.gov Identifier: NCT00159068     History of Changes
Other Study ID Numbers: 391200-HMO-CTIL
Study First Received: September 9, 2005
Last Updated: June 22, 2011
Health Authority: Israel: Israeli Health Ministry Pharmaceutical Administration

Additional relevant MeSH terms:
HIV Infections
Acquired Immunodeficiency Syndrome
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
 Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
Slow Virus Diseases

ClinicalTrials.gov processed this record on June 17, 2013