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The Role of CGRPand Nociceptin in Migraine

The recruitment status of this study is unknown because the information has not been verified recently.
Verified June 2005 by National Taiwan University Hospital.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
National Taiwan University Hospital
ClinicalTrials.gov Identifier:
NCT00155129
First received: September 9, 2005
Last updated: NA
Last verified: June 2005
History: No changes posted
  Purpose

The release of the neuropeptide calcitonin gene-related peptide (CGRP) is thought to play a causative role in migraine. Nociceptin immunoreactivity and ORL-1 mRNA have been detected in human trigeminal ganglia where it was co-localized with CGRP. It may play a role in migraine pathogenesis. We are collecting the blood samples of migraineurs for analysis of these neuropeptides.


Condition
Migraine
Headache

Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Cross-Sectional
Time Perspective: Prospective
Official Title: The Role of Calcitonin Gene-Related Peptide(CGRP)and Nociceptin in the Pathogenesis of Migraine

Resource links provided by NLM:

MedlinePlus related topics: Headache Migraine
U.S. FDA Resources

Further study details as provided by National Taiwan University Hospital:

Estimated Enrollment: 200
Study Start Date: January 2005
Estimated Study Completion Date: June 2005
Detailed Description:

The release of the neuropeptide calcitonin gene-related peptide (CGRP) is thought to play a causative role in migraine. Nociceptin immunoreactivity and ORL-1 mRNA have been detected in human trigeminal ganglia where it was co-localized with CGRP. It may play a role in migraine pathogenesis. We are collecting the blood samples of migraineurs for analysis of these neuropeptides.

  Eligibility

Ages Eligible for Study:   3 Years to 50 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria: patients with headache -

Exclusion Criteria: fever, congenital anomaly, CNS organic lesions

-

  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00155129

Contacts
Contact: Pi-Chuan Fan, MD pcfan@ntumc.org
Contact: Li-Chu Chiou, PhD

Locations
Taiwan
Department of Pediatrics Recruiting
Taipei, Taiwan
Contact: Pi-Chuan Fan, MD     886-2-23123456 ext 5135     pcfan@ntumc.org    
Principal Investigator: Pi-Chuan Fan, MD            
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Principal Investigator: Pi-Chuan Fan Department of Pediatric, NTUH
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00155129     History of Changes
Other Study ID Numbers: 9361701099, 9361701099
Study First Received: September 9, 2005
Last Updated: September 9, 2005
Health Authority: Taiwan: Department of Health

Keywords provided by National Taiwan University Hospital:
migraine
CGRP
nociceptin

Additional relevant MeSH terms:
Headache
Migraine Disorders
Pain
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Headache Disorders, Primary
Headache Disorders
Brain Diseases
Central Nervous System Diseases
 Nociceptin
Calcitonin Gene-Related Peptide
Calcitonin
Vasodilator Agents
Cardiovascular Agents
Therapeutic Uses
Pharmacologic Actions
Bone Density Conservation Agents
Physiological Effects of Drugs

ClinicalTrials.gov processed this record on May 23, 2013