Now Available for Public Comment: Notice of Proposed Rulemaking (NPRM) for FDAAA 801 and NIH Draft Reporting Policy for NIH-Funded Trials

Prevalence of Proteinuria and Chronic Kidney Disease in Pediatric HIV-Infected Patients

This study has been completed.
Sponsor:
Information provided by:
Children's Research Institute
ClinicalTrials.gov Identifier:
NCT00153621
First received: September 8, 2005
Last updated: May 2, 2008
Last verified: September 2005
  Purpose

Among adults with Human Immunodeficiency Virus (HIV) and Acquired Immunodeficiency Syndrome (AIDS), Chronic Kidney Disease (CKD) has previously been reported to occur in approximately 10% of children with HIV-infection. The frequency of CKD, its causes, and its natural history in children and adolescents with HIV-infection have not been systematically studied, particularly in the era of new anti-retroviral medications. The primary aim of this study is to determine the how common pediatric HIV-infected individuals have evidence of persistent proteinuria and CKD.


Condition
Chronic Kidney Failure
AIDS-Associated Nephropathy
HIV Infections

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Prevalence of Proteinuria and Chronic Kidney Disease in Pediatric Patients in the Special Immunology, Burgess, and Nephrology Clinics

Resource links provided by NLM:


Further study details as provided by Children's Research Institute:

Estimated Enrollment: 320
Study Start Date: September 2004
Study Completion Date: September 2007
  Show Detailed Description

  Eligibility

Ages Eligible for Study:   1 Year to 21 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Known/confirmed HIV-infection or AIDS
  • Age > 1 but < 21 years of age
  • Able to tolerate discontinuation of ACEI or ARB
  • Either gender

Exclusion Criteria:

  • HIV negative status
  • Age < 1 or > 21 years of age
  • Unable to tolerate discontinuation of ACEI or ARB
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00153621

Locations
United States, District of Columbia
Children's National Medical Center
Washington, District of Columbia, United States, 20010
Sponsors and Collaborators
Children's Research Institute
Investigators
Principal Investigator: Kevin D. McBryde, MD Children's Research Institute
Study Director: Susan L. Furth, MD, PhD Johns Hopkins University
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00153621     History of Changes
Other Study ID Numbers: 3406, NCRR 1K12RR017613-01
Study First Received: September 8, 2005
Last Updated: May 2, 2008
Health Authority: United States: Institutional Review Board

Keywords provided by Children's Research Institute:
Pediatrics
Chronic Kidney Failure
HIV
Acquired Immunodeficiency Syndrome
AIDS-Associated Nephropathy

Additional relevant MeSH terms:
AIDS-Associated Nephropathy
Acquired Immunodeficiency Syndrome
HIV Infections
Kidney Diseases
Kidney Failure, Chronic
Proteinuria
Renal Insufficiency
Renal Insufficiency, Chronic
Immune System Diseases
Immunologic Deficiency Syndromes
Lentivirus Infections
RNA Virus Infections
Retroviridae Infections
Sexually Transmitted Diseases
Sexually Transmitted Diseases, Viral
Signs and Symptoms
Slow Virus Diseases
Urination Disorders
Urologic Diseases
Urological Manifestations
Virus Diseases

ClinicalTrials.gov processed this record on November 25, 2014