Urokinase Versus Primary Video-Assisted Thorascopic Surgery for Empyema

This study has been completed.

First Received: September 2, 2005 No Changes Posted

Sponsor:	Institute of Child Health
Information provided by:	Institute of Child Health
ClinicalTrials.gov Identifier:	NCT00144950

Purpose

This study will compare VATS versus chest drain insertion and urokinase in the treatment of childhood empema by a randomised prospective study.

Condition	Intervention	Phase
Empyema	Drug: insertion of a chest drain with urokinase instillation Procedure: primary video-assisted thorascopic surgery	Phase I

Study Type:	Interventional
Study Design:	Treatment, Randomized, Open Label, Active Control, Parallel Assignment

Resource links provided by NLM:

MedlinePlus related topics: Surgery

Drug Information available for: Urokinase

U.S. FDA Resources

Further study details as provided by Institute of Child Health:

Primary Outcome Measures:

length of hospital stay

Secondary Outcome Measures:

radiological changes at follow up

Estimated Enrollment:

Eligibility

Ages Eligible for Study:	up to 16 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

patients under the age of 16 referred to GOSH for management of empyema

Exclusion Criteria:

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00144950

Locations

United Kingdom
Great Ormond Street Hospital
London, United Kingdom

Sponsors and Collaborators

Institute of Child Health

Investigators

Principal Investigator:

Adam Jaffe, Dr

Great Ormond Street Hospital

More Information

No publications provided by Institute of Child Health

Additional publications automatically indexed to this study by National Clinical Trials Identifier (NCT ID):

Jaffe A, Calder AD, Owens CM, Stanojevic S, Sonnappa S. Role of routine computed tomography in paediatric pleural empyema. Thorax. 2008 Oct;63(10):897-902. Epub 2008 May 20.

Study ID Numbers:	02AR04
Study First Received:	September 2, 2005
Last Updated:	September 2, 2005
ClinicalTrials.gov Identifier:	NCT00144950 History of Changes
Health Authority:	United Kingdom: Research Ethics Committee

Additional relevant MeSH terms:

Pathologic Processes
Suppuration
Empyema
Infection
Inflammation

ClinicalTrials.gov processed this record on November 05, 2009