A Study to Explore the Association Between Blood Pressure, HIV and Antiretroviral Therapy

This study has been completed.
Sponsor:
Collaborator:
The Hypertension Trust
Information provided by:
Imperial College London
ClinicalTrials.gov Identifier:
NCT00131807
First received: August 18, 2005
Last updated: April 25, 2007
Last verified: April 2007
  Purpose

The purpose of this study is to explore the association between blood pressure, HIV and/or its treatment in a cross sectional observational study.


Condition Intervention
HIV Infections
Procedure: Blood Pressure Measurement
Procedure: Questionnaire

Study Type: Observational
Study Design: Allocation: Random Sample
Observational Model: Natural History
Time Perspective: Cross-Sectional
Official Title: A Study to Explore the Association Between Blood Pressure, HIV and Antiretroviral Therapy

Resource links provided by NLM:


Further study details as provided by Imperial College London:

Estimated Enrollment: 3000
Study Start Date: September 2005
Study Completion Date: September 2006
Detailed Description:

Deaths from AIDS have declined dramatically since the introduction of highly active antiretroviral therapy in HIV infected patients. However the incidence of heart disease has increased four-fold and is now one of the major causes of death in HIV infected patients. While HIV drugs are known to adversely affect serum lipids, the evidence concerning the association between raised blood pressure (a major risk for cardiovascular disease) HIV and/or its treatment is limited and conflicting. The researchers believe it of interest to study heart disease risk factors in patients with HIV infection to avoid one premature cause of death (AIDS) being replaced with another potentially preventable cause of death and disability (heart disease). In this cross sectional observational study the researchers will systematically measure blood pressure and other cardiovascular risk factors in HIV positive patients on and off antiretroviral therapy. These individuals will be matched for age, sex and ethnic group with HIV negative individuals.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Attending St. Mary's sexual health outpatient department
  • Patients willing to give written informed consent
  • Ability to communicate in English

Exclusion Criteria:

  • Failure to give written informed consent in English
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00131807

Locations
United Kingdom
St. Mary's Hospital
Paddington, London, United Kingdom, W2 1NY
Sponsors and Collaborators
Imperial College London
The Hypertension Trust
Investigators
Principal Investigator: Neil R Poulter Imperial College London
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00131807     History of Changes
Other Study ID Numbers: NPSW03
Study First Received: August 18, 2005
Last Updated: April 25, 2007
Health Authority: United Kingdom: Research Ethics Committee

Keywords provided by Imperial College London:
Blood Pressure
HIV
Antiretroviral therapy

Additional relevant MeSH terms:
HIV Infections
Acquired Immunodeficiency Syndrome
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
Slow Virus Diseases

ClinicalTrials.gov processed this record on July 29, 2014