A Study to Explore the Association Between Blood Pressure, HIV and Antiretroviral Therapy
The purpose of this study is to explore the association between blood pressure, HIV and/or its treatment in a cross sectional observational study.
Procedure: Blood Pressure Measurement
|Study Design:||Allocation: Random Sample
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Prospective
|Official Title:||A Study to Explore the Association Between Blood Pressure, HIV and Antiretroviral Therapy|
|Study Start Date:||September 2005|
|Study Completion Date:||September 2006|
Deaths from AIDS have declined dramatically since the introduction of highly active antiretroviral therapy in HIV infected patients. However the incidence of heart disease has increased four-fold and is now one of the major causes of death in HIV infected patients. While HIV drugs are known to adversely affect serum lipids, the evidence concerning the association between raised blood pressure (a major risk for cardiovascular disease) HIV and/or its treatment is limited and conflicting. The researchers believe it of interest to study heart disease risk factors in patients with HIV infection to avoid one premature cause of death (AIDS) being replaced with another potentially preventable cause of death and disability (heart disease). In this cross sectional observational study the researchers will systematically measure blood pressure and other cardiovascular risk factors in HIV positive patients on and off antiretroviral therapy. These individuals will be matched for age, sex and ethnic group with HIV negative individuals.
|St. Mary's Hospital|
|Paddington, London, United Kingdom, W2 1NY|
|Principal Investigator:||Neil R Poulter||Imperial College London|