Word-Retrieval for Aphasia
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Purpose
The purpose of this investigation is to further develop and test a treatment for word-finding problems in aphasia. The treatment is designed to strengthen meaning associations within categories of words (e.g., animals, tools, fruits). The treatment is also designed to be used as a search strategy in instances of word-finding difficulty. The study was devised to evaluate the extent to which treatment increases the ability to recall trained, as well as untrained, words.
| Condition | Intervention |
|---|---|
|
Aphasia Language Disorders Speech Disorders |
Behavioral: Semantic Feature Training |
| Study Type: | Interventional |
| Study Design: | Allocation: Non-Randomized Endpoint Classification: Efficacy Study Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Treatment |
| Official Title: | Word-Retrieval for Aphasia: Facilitation of Generalization |
- Generalization of word retrieval skills [ Time Frame: 6 weeks following completion of treatment ] [ Designated as safety issue: No ]
| Enrollment: | 10 |
| Study Start Date: | September 2004 |
| Study Completion Date: | April 2013 |
| Primary Completion Date: | September 2010 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Arm 1
single subject design (24 participants)
|
Behavioral: Semantic Feature Training
The treatment is designed to stimulate the semantic feature network so that it may serve as not only a mechanism for improving disrupted lexical semantic processing, but also as a compensatory strategy during word retrieval failures.
|
Detailed Description:
The purpose of the proposed research is to examine the effects of a semantically-oriented treatment on word retrieval in persons with aphasia. The planned investigations are designed to further the development of semantic feature training so that it may serve as not only a mechanism for improving disrupted lexical semantic processing, but also as a compensatory strategy during word retrieval failures. The proposed research will also address the issue of exemplar typicality (Kiran & Thompson, 2003) by examining the effects of training typical versus atypical exemplars of various categories with individuals with different types of aphasia. A series of 24 single subject experimental designs will be conducted in the context of a group design to address the following experimental questions:
- Will training atypical examples of living and artifact noun categories using semantic feature training result in a significantly different outcome* than training typical examples of living and artifact noun categories?
- Will training of one category of nouns using semantic feature training result in improved retrieval of untrained categories of nouns?
- Will effects of semantic feature training vary across aphasia types?
- Will semantic feature training result in increased production of content during discourse?
Will generalization to untrained typical examples vary across generalization lists that are repeatedly exposed and those that are limited in exposure? (i.e., Does repeated exposure appear to contribute to generalization?)
- Outcome measure will reflect acquisition, response generalization within category, and response generalization across category effects of treatment.
Eligibility| Ages Eligible for Study: | 21 Years to 75 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Diagnosis of Wernicke's, Broca's, or Conduction aphasia with significant word-retrieval deficits
- At least 6 months post-onset of single, left-hemisphere stroke
- Minimum of high-school education
- Visual and auditory acuity sufficient for experimental tasks
- Nonverbal intelligence within normal limits
Exclusion Criteria:
- Diagnosed mental illness other than depression
- Neurological condition other than that which resulted in aphasia
- History of alcohol or substance abuse
- Non-native English speaker
- Premorbid history of speech/language disorder
Contacts and Locations| United States, Utah | |
| VA Salt Lake City Health Care System, Salt Lake City | |
| Salt Lake City, Utah, United States, 84148 | |
| Principal Investigator: | Julie L. Wambaugh, PhD | VA Salt Lake City Health Care System, Salt Lake City |
More Information
No publications provided
| Responsible Party: | Department of Veterans Affairs |
| ClinicalTrials.gov Identifier: | NCT00125242 History of Changes |
| Other Study ID Numbers: | C3826-R |
| Study First Received: | July 27, 2005 |
| Last Updated: | April 15, 2013 |
| Health Authority: | United States: Federal Government |
Keywords provided by Department of Veterans Affairs:
|
Aphasia Language therapy Rehabilitation of speech and language disorders Speech-language pathology |
Additional relevant MeSH terms:
|
Aphasia Language Disorders Speech Disorders Communication Disorders |
Neurobehavioral Manifestations Neurologic Manifestations Nervous System Diseases Signs and Symptoms |
ClinicalTrials.gov processed this record on May 16, 2013