The Effect of Caffeine in Elderly Citizens
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Purpose
The study investigated the effect of caffeine on physical performance in healthy citizens aged over 70 years. The main hypothesis was that 6 mg/kg caffeine would improve cycling endurance at 65% of expected maximal heart rate.
| Condition | Intervention | Phase |
|---|---|---|
|
Healthy Elderly Citizens |
Drug: Caffeine |
Phase 4 |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Crossover Assignment Masking: Double-Blind Primary Purpose: Treatment |
| Official Title: | The Effect of Caffeine as Endurance Enhancing Drug in the Elderly |
- endurance measured on an ergometer bicycle
- postural stability
- reactiontime
- isometric endurance (armflexion)
- walking speed
- fatigue
| Estimated Enrollment: | 30 |
| Study Start Date: | July 2002 |
| Estimated Study Completion Date: | March 2006 |
Caffeine ingestion increases the endurance of young people exercising at 60%-85% of their maximal oxygen uptake, and it also seems to improve endurance as measured by repeated sub-maximal isometric contraction and decreases the rate of perceived exertion during exercise. Although caffeine increases endurance in young people, an increase in endurance may be of greater interest in the elderly as the population of older adults with a physically active lifestyle is growing rapidly or for increasing endurance fitness through an exercise or rehabilitation program. Therefore the main hypothesis was that caffeine would improve cycling endurance at 65% of expected maximal heart rate, and the secondary hypotheses were that caffeine would improve postural stability, reaction and movement times, isometric arm flexion endurance, and walking speed, and would reduce the rate of perceived exertion after 5 minutes of cycling in healthy elderly citizens.
Eligibility| Ages Eligible for Study: | 70 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Healthy elderly individuals aged over 70 years
Exclusion Criteria:
- Dementia or invalidating psychiatric disease
- General debility, angina, or other diseases that would render participation in the test program impossible
- Treatment with beta receptor blocking drugs, calcium-channel blocking drugs, digitalis, or nitroglycerine
- Acute disease and injury
- Diabetes
- Conditions that would contraindicate caffeine ingestion or participation in the test program
- Treatment with medication that interacts with caffeine
- Ingestion of caffeine containing drinks and foods 48 hours before each session
Contacts and Locations| Denmark | |
| Surgical Research Department | |
| Herning, Ringkjoebing, Denmark, 7400 | |
| Principal Investigator: | Charlotte B Norager, M.D | Surgical Research Department, Herning Hospital, DK-7400 Herning |
More Information
No publications provided
| ClinicalTrials.gov Identifier: | NCT00117520 History of Changes |
| Other Study ID Numbers: | 2612-1987 |
| Study First Received: | June 30, 2005 |
| Last Updated: | July 3, 2006 |
| Health Authority: | Denmark: National Board of Health |
Keywords provided by Herning Hospital:
|
caffeine, endurance, postural stability, elderly |
Additional relevant MeSH terms:
|
Caffeine Central Nervous System Stimulants Physiological Effects of Drugs Pharmacologic Actions Central Nervous System Agents Therapeutic Uses Phosphodiesterase Inhibitors |
Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action Purinergic P1 Receptor Antagonists Purinergic Antagonists Purinergic Agents Neurotransmitter Agents |
ClinicalTrials.gov processed this record on May 19, 2013