Interactions Between Cranberry Juice and Antibiotics Used to Treat Urinary Tract Infections - Full Text View

Sponsor:	National Center for Complementary and Alternative Medicine (NCCAM)
Information provided by:	National Center for Complementary and Alternative Medicine (NCCAM)
ClinicalTrials.gov Identifier:	NCT00084201

Purpose

The purpose of study is to determine whether cranberry juice interacts with antibiotics used to treat urinary tract infections (UTIs).

Condition	Intervention
Urinary Tract Infections	Drug: Cranberry juice Drug: Amoxicillin

Study Type:	Interventional
Study Design:	Treatment, Non-Randomized, Open Label, Active Control, Crossover Assignment, Pharmacokinetics Study
Official Title:	Cranberry: Interactions With Anti-Infectious Agents

Resource links provided by NLM:

MedlinePlus related topics: Antibiotics Urinary Tract Infections

Drug Information available for: Amoxicillin Amoxicillin sodium Amoxicillin trihydrate

U.S. FDA Resources

Further study details as provided by National Center for Complementary and Alternative Medicine (NCCAM):

Primary Outcome Measures:

Drug Elmination

Secondary Outcome Measures:

Drug absorption

Estimated Enrollment:	18
Study Start Date:	July 2006
Estimated Study Completion Date:	June 2007

Detailed Description:

Although evidence of its effectiveness is limited, cranberry juice is widely used to prevent urinary tract infections (UTIs). However, recent studies have shown that cranberry juice may affect the way the body absorbs and metabolizes antibiotics used to treat UTIs. This study will determine whether concurrent cranberry juice administration lowers the urinary concentrations of two commonly used antibiotics, amoxicillin and cefaclor.

This study will involve children being treated for UTIs and adults without UTIs. All of the children will continue their prescribed amoxicillin/cefaclor treatment. After 7 to 10 days of antibiotic treatment, the children will be assigned to receive either cranberry juice for 2 days or no additional treatment. Urine samples will be collected from all child participants before and after the administration of cranberry juice to examine the excretion of the antibiotics.

Adult participants will receive two different doses of amoxicillin, with or without cranberry juice. Blood and urine samples will be collected to evaluate the effect of cranberry juice on the absorption and elimination of amoxicillin.

Eligibility

Ages Eligible for Study:	6 Years to 50 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria for Children:

Urinary tract infection (UTI) treated with cefaclor or amoxicillin

Inclusion Criteria for Adults:

No UTI

Exclusion Criteria:

Allergies to antibiotics
Use of medications other than oral contraceptives
Pregnancy or breast-feeding
Smoker

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00084201

Locations

United States, Washington
University of Washington
Seattle, Washington, United States, 98195

Sponsors and Collaborators

National Center for Complementary and Alternative Medicine (NCCAM)

Investigators

Principal Investigator:

Gail D Anderson, PhD

University of Washington

More Information

No publications provided

Study ID Numbers:	R21 AT002077-01
Study First Received:	June 8, 2004
Last Updated:	November 28, 2006
ClinicalTrials.gov Identifier:	NCT00084201 History of Changes
Health Authority:	United States: Federal Government

Keywords provided by National Center for Complementary and Alternative Medicine (NCCAM):

Vaccinium macrocarpon

Additional relevant MeSH terms:

Anti-Infective Agents
Anti-Bacterial Agents
Communicable Diseases
Amoxicillin
Urologic Diseases

Therapeutic Uses
Urinary Tract Infections
Infection
Pharmacologic Actions

ClinicalTrials.gov processed this record on February 08, 2010