DISEASE CHARACTERISTICS:

• Histologically confirmed renal cell carcinoma

  • Metastatic disease
  • No pure papillary or sarcomatoid variants
• Measurable disease

• Failed prior subcutaneous OR intravenous (dose ≤ 50,000 IU/kg/day) interleukin-2

  • Documented disease progression
• No estimated hepatic replacement by tumor > 25% by CT scan or MRI
• No tumor involving the CNS or a major nerve

PATIENT CHARACTERISTICS:

Age

• 18 and over

Performance status

• Karnofsky 80-100%

Life expectancy

• More than 3 months

Hematopoietic

• Platelet count ≥ 80,000/mm^3
• No sites of ongoing bleeding

Hepatic

• See Disease Characteristics
• Bilirubin ≤ 1.4 mg/dL
• AST and ALT ≤ 3 times normal
• PT or PTT INR ≤ 1.2
• Hepatitis B surface antigen negative
• Hepatitis C virus negative
• No coagulation disorders

Renal

• Creatinine ≤ 1.6 mg/dL

Cardiovascular

• No ongoing ischemia*
• No cardiac dysfunction*
• No abnormal ejection fraction* NOTE: *A cardiac stress test is indicated for all patients ≥ 50 years of age and for any patient with possible cardiac disease as suggested by history, physical exam, or electrocardiogram

Pulmonary

• FEV_1 ≤ 65% of predicted*
• Vital capacity ≤ 65% of predicted* NOTE: *Pulmonary function tests are to be performed on any patient with a significant smoking history or suspected pulmonary disease either by history, physical exam, or radiograph

Other

• HIV negative
• No AIDS
• No systemic infections
• No other malignancy except carcinoma in situ
• No psychiatric illness that would preclude study participation or compliance
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY:

Biologic therapy

• See Disease Characteristics

Chemotherapy

• Not specified

Endocrine therapy

• No concurrent steroids

Radiotherapy

• Not specified

Surgery

• Not specified

Other

• More than 28 days since other prior treatment for renal cell cancer
• No concurrent immunosuppressive agents