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Insulin Resistance and Insulin Secretion

This study has been completed.

Sponsored by: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Information provided by: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
ClinicalTrials.gov Identifier: NCT00073294
  Purpose

This is a pilot study to examine the prevalence of metabolic risk factors (impaired insulin release and impaired insulin sensitivity) for type 2 diabetes mellitus in children and adults from a population that is at high risk for this disease. We hypothesize that at least one of these pre-diabetic traits will be evident in a large proportion of relatives of known type 2 diabetic children as compared to a control group of subjects without a family history of type 2 diabetes. By isolating these traits, it will be possible to determine the relative contributions of genes and environment to each trait and to identify those at risk for subsequent development of type 2 diabetes by virtue of having one trait. Ultimately, those individuals at risk, especially those with impaired insulin release, would hopefully benefit from intervention to prevent the weight gain that will 'unmask' their underlying pancreatic dysfunction and thus prevent or retard the development of type 2 diabetes.


Condition Intervention
Diabetes Mellitus, Type 2
Behavioral: diet

MedlinePlus related topics:   Diabetes   

Drug Information available for:   Insulin   

U.S. FDA Resources

Study Type:   Interventional
Study Design:   Prevention, Non-Randomized, Single Blind, Uncontrolled, Single Group Assignment, Bio-equivalence Study
Official Title:   Phenotypic Assessment of Insulin Resistance and Insulin Secretory Capacity

Further study details as provided by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK):

Estimated Enrollment:   200

  Eligibility
Ages Eligible for Study:   10 Years to 20 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Criteria

Ascertainment criteria for probands:

  • age 10-20 years and
  • obesity (BMI >85% for sex and age)
  • diabetic criteria as described above or family history (first or second degree relative) with type 2 diabetes
  Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00073294

Locations
United States, New York
Columbia Presbyterian Medical Center/ Irving Center    
      New York, New York, United States, 10032
Russ Berrie Pavilion    
      New York, New York, United States, 10032

Sponsors and Collaborators
  More Information


Study ID Numbers:   9777
First Received:   November 18, 2003
Last Updated:   December 6, 2007
ClinicalTrials.gov Identifier:   NCT00073294
Health Authority:   United States: Federal Government

Keywords provided by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK):
diabetes  

Study placed in the following topic categories:
Hyperinsulinism
Metabolic Diseases
Diabetes Mellitus, Type 2
Diabetes Mellitus
Endocrine System Diseases
Endocrinopathy
Insulin Resistance
Metabolic disorder
Glucose Metabolism Disorders
Insulin

Additional relevant MeSH terms:
Hypoglycemic Agents
Physiological Effects of Drugs
Pharmacologic Actions

ClinicalTrials.gov processed this record on November 30, 2008




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