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Low-Dose Leptin and the Formerly-Obese

This study has been completed.

Sponsored by: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Information provided by: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
ClinicalTrials.gov Identifier: NCT00073242
  Purpose

Our previous studies have demonstrated that there is substantial metabolic opposition to the maintenance of an altered body weight. Leptin is a protein secreted by fat cells and the circulating concentrations of leptin are directly proportional to fat mass. Leptin-deficiency is associated with severe obesity in rodents and in humans and the obesity is relieved by leptin administration. These studies examine the hypothesis that some of this metabolic opposition cto the maintenance of an altered body weight can be relieved by restoring circulating concentrations of the hormone leptin to the same range as at usual body weight in subjects who are maintaining a reduced body weight. The basic design of this study is to observe subjects at a 10% reduced body weight and then again at that reduced body weight while receiving physiological leptin supplementation.


Condition Intervention
Obesity
Behavioral: Dietary modification
Drug: Leptin

MedlinePlus related topics:   Obesity   

Drug Information available for:   Leptin   

U.S. FDA Resources

Study Type:   Interventional
Study Design:   Treatment, Non-Randomized, Single Blind, Uncontrolled, Single Group Assignment, Safety Study
Official Title:   Effects of Low-Dose Leptin on the Metabolic/Behavioral Phenotypes of the Formerly-Obese

Further study details as provided by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK):

Estimated Enrollment:   25
Estimated Study Completion Date:   June 2008

  Eligibility
Ages Eligible for Study:   19 Years to 45 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Criteria

Healthy

  Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00073242

Locations
United States, New York
Columbia Presbyterian Medical Center    
      New York, New York, United States, 10032

Sponsors and Collaborators
  More Information


Study ID Numbers:   9631
First Received:   November 18, 2003
Last Updated:   December 6, 2007
ClinicalTrials.gov Identifier:   NCT00073242
Health Authority:   United States: Federal Government

Keywords provided by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK):
leptin  
obesity  

Study placed in the following topic categories:
Body Weight
Signs and Symptoms
Obesity
Nutrition Disorders
Overweight
Overnutrition

ClinicalTrials.gov processed this record on November 30, 2008




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