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| Sponsors and Collaborators: |
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) M.D. Anderson Cancer Center |
|---|---|
| Information provided by: | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) |
| ClinicalTrials.gov Identifier: | NCT00069589 |
Purpose
Alopecia areata is the loss of hair in patches that can proceed to loss of all hair (alopecia totalis or universalis). The purpose of the registry is to collect patient information and blood samples from people with alopecia areata.
| Condition |
|---|
|
Alopecia Areata Alopecia Totalis Alopecia Universalis Autoimmune Hair Loss Alopecia Partialis |
| Study Type: | Observational |
| Study Design: | Case Control, Prospective |
| Official Title: | Alopecia Areata Registry and Immunogenetic Mechanisms |
DNA will be analyzed to learn the link between gene markers of traites of alopecia areata. Sera will be used to analyse cytokins. Lymphocytes will be used for the creation of B-cell lines.
| Estimated Enrollment: | 3100 |
| Study Start Date: | November 2001 |
| Estimated Study Completion Date: | September 2010 |
Alopecia areata is a condition in which hair is lost either from part of the scalp, all of the scalp, or the entire body, and it affects 1% to 2% of the population. It is thought to be an autoimmune disease and in some cases the disease is hereditary. The Alopecia Areata Registry will collect information and blood samples from clinically well-characterized patients with these three forms of alopecia areata: alopecia partialis (patchy loss of the scalp hair), alopecia totalis (total loss of all scalp hair), and alopecia universalis (complete loss of all hair everywhere on the body). This will be a collection of patients in multi-generational families, twins, single patients with patchy, persistent transient alopecia areata or long-standing alopecia totalis/universalis and with controls (persons unaffected and not related to alopecia patients). Information from these patients will be used to search the human genome for disease-associated loci and/or genes. Researchers interested in doing pathophysiology or treatment studies of this disease will also be able to contact patients having the appropriate form of the disease for the studies in question.
Patients who have been diagnosed with alopecia areata by a dermatologist will be eligible for the registry. Patients will fill out an information form online (alopeciaareataregistry.org). Patients who have a family history or specific types of alopecia will be invited to participate in a more detailed questionnaire and physical exam and have blood samples drawn.
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Probability Sample |
Patients with alopecia areata (AA), both children and adults, who have been diagnosed by a physician with alopecia universalis, alopecia totalis, patchy persistent AA, or transient mild AA. Family members (related by blood) of these patients, preferably sib-pairs plus parents and multiplex families(persons with at least three family members with AA or alopecia universalis and alopecia totalis).
Also, healthy individuals who are unaffected, non-blood related individuals and do not live in the same household with alopecia areata patient are needed as controls.
Inclusion Criteria
Accepts Health Volunteers: Non blood-related individuals who are unaffected with alopecia areata and do not live in the same household with alopecia areata patient.
Contacts and Locations| Contact: Alopecia Areata Registry Patient Recruitment | 713-792-5999 | alopeciaregistry@mdanderson.org |
| Contact: Alopecia Areata Registry Toll Free Number | 1-866-837-1050 |
| United States, California | |
| University of California, San Francisco | Recruiting |
| San Francisco, California, United States, 94143 | |
| Contact: Charles Chiang, MD 415-353-4333 | |
| Sub-Investigator: Vera Price, MD | |
| United States, Colorado | |
| University of Colorado - UCHSC - Health Science Center at Fitzsimons | Recruiting |
| Aurora, Colorado, United States, 80010-7163 | |
| Contact: Lisa Maestas 303-724-4032 Lisa.Maestas@uchsc.edu | |
| Sub-Investigator: David Norris, MD | |
| United States, Minnesota | |
| University of Minnesota | Recruiting |
| Minneapolis, Minnesota, United States, 55455 | |
| Contact: Chelsy Jungbluth 612-625-9338 | |
| Sub-Investigator: Maria Hordinsky, MD | |
| United States, New York | |
| Columbia University | Recruiting |
| New York, New York, United States, 10032 | |
| Contact: Carol Coppola, RN 212-305-6953 cc2241@columbia.edu | |
| Sub-Investigator: Angela Christiano, PhD | |
| United States, Texas | |
| M.D. Anderson Cancer Center | Recruiting |
| Houston, Texas, United States, 77030 | |
| Contact: Joyce Osei, MPH, MHA 713-794-1442 jsosei@mdanderson.org | |
| Principal Investigator: Madeleine Duvic, MD | |
| Principal Investigator: | Madeleine Duvic, MD | M.D. Anderson Cancer Center |
More Information
| Responsible Party: | University of Texas, M.D. Anderson Cancer Center ( Madeleine Duvic, M.D. Principle Investigator ) |
| Study ID Numbers: | NIAMS-097, HHSN268200682279C |
| Study First Received: | September 29, 2003 |
| Last Updated: | June 17, 2009 |
| ClinicalTrials.gov Identifier: | NCT00069589 History of Changes |
| Health Authority: | United States: Federal Government |
|
Baldness Autoimmunity Hair Alopecia Areata |
Alopecia Partialis Alopecia Totalis Alopecia Universalis Autoimmune Hair Loss |
|
Alopecia Universalis Pathological Conditions, Anatomical Alopecia Areata Hypotrichosis |
Skin Diseases Alopecia Alopecia Totalis |
|
Pathological Conditions, Anatomical Hair Diseases Alopecia Areata |
Hypotrichosis Skin Diseases Alopecia |