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Oxidative Stress and Vitamin E Requirements

This study has been completed.

Sponsored by: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Information provided by: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
ClinicalTrials.gov Identifier: NCT00067899
  Purpose

The purpose of this study is to determine if oxidative stress derived from cigarette smoking increases vitamin E requirements. The study will also assess the role of vitamin C in modulating vitamin E requirements. Vitamin E requirements will be assessed by measuring vitamin E in plasma as well as by measuring the excreted metabolite in the urine.


Condition Intervention Phase
Smoking
Drug: Vitamin E with and without Vitamin C
Phase II

MedlinePlus related topics:   Smoking    Stress   

Drug Information available for:   Vitamin E    alpha-Tocopherol    alpha-Tocopheryl acetate    Tocopherols    Ascorbic acid   

U.S. FDA Resources

Study Type:   Interventional
Study Design:   Treatment, Randomized, Double-Blind, Placebo Control, Crossover Assignment, Pharmacokinetics Study

Further study details as provided by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK):

Estimated Enrollment:   99
Study Start Date:   September 2000

Detailed Description:

We will be investigating the fractional disappearance rate of tocopherols in cigarette smokers compared to nonsmokers. This will be accomplished by supplementing individuals with deuterium labeled alpha- and gamma-tocopherols. Quantification of plasma tocopherols as well as urinary metabolites, alpha- and gamma-CEHC, will be determined using LC/MS analysis. In addition, the role of vitamin C as it pertains to its influence on the fraction disappearance rate of vitamin E will also be evaluated.

  Eligibility
Ages Eligible for Study:   18 Years to 35 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Criteria
  • Nonsmokers and Smokers (>10 cigarettes)
  • Non-nutritional supplement user
  • Free of disease
  • Total cholesterol < 240 mg/dl
  • Triglycerides < 200 mg/dl
  • < 5hrs/week of aerobic exercise
  Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00067899

Locations
United States, Oregon
Linus Pauling Institute - Oregon State University    
      Corvallis, Oregon, United States, 97331

Sponsors and Collaborators
  More Information


Publications:

Study ID Numbers:   OSVER
First Received:   August 29, 2003
Last Updated:   July 5, 2005
ClinicalTrials.gov Identifier:   NCT00067899
Health Authority:   United States: Federal Government

Keywords provided by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK):
cigarette smoking  
tocopherol  
bioavailability  
metabolism  
oxidative stress  

Study placed in the following topic categories:
Tocopherols
Smoking
Tocopherol acetate
Vitamin E
Stress
Ascorbic Acid
Alpha-Tocopherol

Additional relevant MeSH terms:
Habits
Antioxidants
Molecular Mechanisms of Pharmacological Action
Growth Substances
Vitamins
Physiological Effects of Drugs
Micronutrients
Protective Agents
Pharmacologic Actions

ClinicalTrials.gov processed this record on November 30, 2008




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