Oxidative Stress and Vitamin E Requirements - Full Text View

Purpose

The purpose of this study is to determine if oxidative stress derived from cigarette smoking increases vitamin E requirements. The study will also assess the role of vitamin C in modulating vitamin E requirements. Vitamin E requirements will be assessed by measuring vitamin E in plasma as well as by measuring the excreted metabolite in the urine.

Condition	Intervention	Phase
Smoking	Drug: Vitamin E with and without Vitamin C	Phase II

MedlinePlus related topics:

Smoking Stress

Drug Information available for:

Vitamin E alpha-Tocopherol alpha-Tocopheryl acetate Tocopherols Ascorbic acid

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Randomized, Double-Blind, Placebo Control, Crossover Assignment, Pharmacokinetics Study

Further study details as provided by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK):

Estimated Enrollment:	99
Study Start Date:	September 2000

Detailed Description:

We will be investigating the fractional disappearance rate of tocopherols in cigarette smokers compared to nonsmokers. This will be accomplished by supplementing individuals with deuterium labeled alpha- and gamma-tocopherols. Quantification of plasma tocopherols as well as urinary metabolites, alpha- and gamma-CEHC, will be determined using LC/MS analysis. In addition, the role of vitamin C as it pertains to its influence on the fraction disappearance rate of vitamin E will also be evaluated.

Eligibility

Ages Eligible for Study:	18 Years to 35 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Nonsmokers and Smokers (>10 cigarettes)
Non-nutritional supplement user
Free of disease
Total cholesterol < 240 mg/dl
Triglycerides < 200 mg/dl
< 5hrs/week of aerobic exercise

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00067899

Locations


United States, Oregon
	Linus Pauling Institute - Oregon State University
	Corvallis, Oregon, United States, 97331

Sponsors and Collaborators

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

More Information

Publications:

Traber MG, Winklhofer-Roob BM, Roob JM, Khoschsorur G, Aigner R, Cross C, Ramakrishnan R, Brigelius-Flohe R. Vitamin E kinetics in smokers and nonsmokers. Free Radic Biol Med. 2001 Dec 1;31(11):1368-74.

Dietrich M, Block G, Norkus EP, Hudes M, Traber MG, Cross CE, Packer L. Smoking and exposure to environmental tobacco smoke decrease some plasma antioxidants and increase gamma-tocopherol in vivo after adjustment for dietary antioxidant intakes. Am J Clin Nutr. 2003 Jan;77(1):160-6.

Traber MG, van der Vliet A, Reznick AZ, Cross CE. Tobacco-related diseases. Is there a role for antioxidant micronutrient supplementation? Clin Chest Med. 2000 Mar;21(1):173-87, x. Review.

Study ID Numbers:	OSVER
First Received:	August 29, 2003
Last Updated:	July 5, 2005
ClinicalTrials.gov Identifier:	NCT00067899
Health Authority:	United States: Federal Government

Keywords provided by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK):

cigarette smoking

tocopherol

bioavailability

metabolism

oxidative stress

Study placed in the following topic categories:

Tocopherols

Smoking

Tocopherol acetate

Vitamin E

Stress

Ascorbic Acid

Alpha-Tocopherol

Additional relevant MeSH terms:

Habits

Antioxidants

Molecular Mechanisms of Pharmacological Action

Growth Substances

Vitamins

Physiological Effects of Drugs

Micronutrients

Protective Agents

Pharmacologic Actions

ClinicalTrials.gov processed this record on November 30, 2008

Sponsored by:	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Information provided by:	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
ClinicalTrials.gov Identifier:	NCT00067899