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| Sponsored by: |
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) |
| Information provided by: | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) |
| ClinicalTrials.gov Identifier: | NCT00064805 |
Purpose
Adults who sustain brain damage due to stroke, head injury, or traumatic surgery may develop difficulty reading. This study examines the effectiveness of behavior-based programs to improve reading ability in these individuals.
| Condition | Intervention |
|
Dyslexia, Acquired Brain Injuries Cerebrovascular Accident |
Behavioral: Cognitive Therapy to Improve Reading |
| MedlinePlus related topics: | Traumatic Brain Injury |
| Study Type: | Interventional |
| Study Design: | Treatment, Non-Randomized, Open Label, Active Control, Parallel Assignment, Efficacy Study |
| Official Title: | Cognitively-Based Treatments of Acquired Dyslexias |
| Estimated Enrollment: | 58 |
| Study Start Date: | August 2002 |
| Estimated Study Completion Date: | July 2007 |
Acquired disorders of reading (acquired dyslexia) are common in patients with aphasia subsequent to left hemisphere stroke. Even when language functions recover sufficiently to enable the patient to return to work, continuing dyslexia often interferes significantly with job performance. This study will evaluate cognitive therapies for the treatment of acquired dyslexia.
Each therapy is based upon a cognitive neuropsychological model of reading; the therapies target specific types of reading deficit and stem from the question of re-learning versus re-organization of function. The therapies focus on dyslexic disorders stemming from the following underlying deficits: 1) impaired access to the orthographic word form from the visual modality (pure alexia); 2) impaired orthographic/phonologic connections (phonologic/deep dyslexia); and 3) decreased ability to hold phonologic codes in memory (phonologic text alexia).
Participants in this study will undergo a comprehensive and detailed battery of reading and reading-related tests to determine the underlying impairment causing the reading deficit. Based upon the results of these tests, the patient's dyslexic disorder will be characterized and, if appropriate, the patient will be assigned to one of the treatment programs devised specifically for that type of deficit. Treatment programs are evaluated for efficacy by comparing the accuracy and speed of reading pre- and post-treatment.
Eligibility
| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria
Exclusion Criteria
Contacts and Locations| Contact: Sarah F. Snider, MA, SLP | sfs24@georgetown.edu | |
| Contact: Nora L. Watson, BS | nlw9@georgetown.edu |
| United States, District of Columbia | |||||
| Georgetown University Medical Center | Recruiting | ||||
| Washington, District of Columbia, United States, 20057 | |||||
| Principal Investigator: | Rhonda B. Friedman, Ph.D. | Georgetown University Medical School |
More Information
Cognitive Neuropsychology Lab at Georgetown University Medical Center 
  |
| Study ID Numbers: | R01HD36019 |
| First Received: | July 14, 2003 |
| Last Updated: | September 11, 2008 |
| ClinicalTrials.gov Identifier: | NCT00064805 |
| Health Authority: | United States: Federal Government |
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