Aortic Calcium: Epidemiology and Progression -- Ancillary to MESA

This study has been completed.
Sponsor:
Collaborator:
Information provided by (Responsible Party):
Dr. Michael H. Criqui, University of California, San Diego
ClinicalTrials.gov Identifier:
NCT00059124
First received: April 17, 2003
Last updated: July 10, 2013
Last verified: July 2013
  Purpose

To study the epidemiology of aortic calcium.


Condition
Cardiovascular Diseases
Heart Diseases
Atherosclerosis
Coronary Arteriosclerosis

Study Type: Observational
Study Design: Observational Model: Ecologic or Community
Time Perspective: Prospective
Official Title: Aortic Calcium: Epidemiology and Progression

Resource links provided by NLM:


Further study details as provided by University of California, San Diego:

Primary Outcome Measures:
  • Abdominal Aortic Calcium [ Time Frame: During the Exam 2 and Exam 3 MESA visits ] [ Designated as safety issue: No ]

Enrollment: 1980
Study Start Date: March 2003
Study Completion Date: February 2008
Primary Completion Date: February 2008 (Final data collection date for primary outcome measure)
Detailed Description:

BACKGROUND:

Aortic calcium measured by computed tomography occurs earlier in life than other subclinical (that is, asymptomatic) markers of cardiovascular disease (CVD), shows a wide range, and is common in women. The large size of the aorta and relative lack of image artifact from motion make it ideal for radiographic quantitative imaging. This study is ancillary to and coordinated with the Multi-Ethnic Study of Atherosclerosis (MESA), a large prospective epidemiologic study investigating multiple subclinical CVD measures and CVD risk factors. Subclinical measures in MESA include coronary calcium, carotid ultrasound, cardiac magnetic resonance imaging, and the ankle/brachial blood pressure index. The extensive CVD risk factor measurements include both traditional risk factors and newer measures such as inflammatory and genetic markers.

DESIGN NARRATIVE:

This ancillary study will determine the epidemiology of aortic calcium in 2000 randomly selected (from 6500 total) MESA participants. Questions to be addressed include predictors of aortic calcium progression; associations of aortic calcium and aortic calcium progression with other subclinical CVD measures, CVD risk factors, and demographics; and the prognostic significance of aortic calcium. The project has three primary specific aims: 1) to predict the cross-sectional aortic calcium burden as a function of other subclinical CVD measures and CVD risk factors; 2) to predict aortic calcium progression as a function of other subclinical CVD measures and CVD risk factors, and 3) to predict aortic calcium progression as a function of progression of selected subclinical CVD measures and CVD risk factors. The two secondary specific aims are 1) to contrast the results of the three primary specific aims for men vs. women, and for four major ethnic groups (White, Hispanic, Black, and Asian); and 2) to provide a database for future evaluation of whether aortic calcium and/or aortic calcium progression independently predict subsequent myocardial infarction, stroke, and other CVD events.

  Eligibility

Ages Eligible for Study:   45 Years to 84 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

A random selection of approximately 1/3 of the original MESA participants.

Criteria

Participation in the original MESA Study

  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00059124

Sponsors and Collaborators
University of California, San Diego
Investigators
Principal Investigator: Michael H Criqui, MD, MPH University of California, San Diego
  More Information

No publications provided

Responsible Party: Dr. Michael H. Criqui, Distinguished Professor, University of California, San Diego
ClinicalTrials.gov Identifier: NCT00059124     History of Changes
Other Study ID Numbers: 1213, R01HL072403
Study First Received: April 17, 2003
Last Updated: July 10, 2013
Health Authority: United States: Federal Government

Additional relevant MeSH terms:
Arteriosclerosis
Atherosclerosis
Cardiovascular Diseases
Coronary Artery Disease
Heart Diseases
Myocardial Ischemia
Arterial Occlusive Diseases
Coronary Disease
Vascular Diseases

ClinicalTrials.gov processed this record on October 21, 2014