Inclusion Criteria

• Histologically or cytologically confirmed diagnosis of ovarian cancer
• Subjects must have received 1-2 regimens of prior chemotherapy (with one containing paclitaxel)
• At least 18 years of age
• Bidimensionally measurable disease amenable to CT scanning. At least one lesion must be least 1 X 1 cm in size.
• Karnofsky performance status of at least 70%
• Estimated life expectancy of at least 12 weeks
• Females of childbearing potential must have a negative pregnancy test and agree to use an effective contraceptive
• Subject must be able to comply with study procedures and follow-up examinations.
• Signed written informed consent
• Lab Values (obtained ≤ 7 days prior to study enrollment):
• ANC at least 1.5x10e9/L,
• Platelet count at least 100x10e9/L,
• Hemoglobin at least 8.5 g/dL,
• Creatinine within 2 times upper limit of normal
• AST and ALT within 3 times upper limit of normal
• Bilirubin within 1.5 times upper limit of normal
• Albumin great than 2.5 g/dL
• INR < 1.5 for subjects without anticoagulants

Exclusion Criteria

• Severe, concurrent disease, infection or co-morbidity that, in the judgment of the investigator, would make the subject inappropriate for enrollment
• NYHA Class III/IV cardiac disease, left ventricular ejection fraction (LVEF) of <50%, or acute anginal symptoms
• Patients who have received any investigational agent within 4 weeks of enrollment
• Patients who are pregnant or breast-feeding
• History of prior malignancy other than ovarian cancer within the last 5 years, except for adequately treated basal cell or squamous cell skin cancer or carcinoma in situ of the cervix
• History of central nervous system metastases or carcinomatous meningitis
• Major surgery within 4 weeks of enrollment