Mohawk Culture, Behavior, Toxicant Exposure and Health

The recruitment status of this study is unknown because the information has not been verified recently.
Verified August 2002 by National Institute of Environmental Health Sciences (NIEHS).
Recruitment status was  Recruiting
Sponsor:
Information provided by:
National Institute of Environmental Health Sciences (NIEHS)
ClinicalTrials.gov Identifier:
NCT00043238
First received: August 7, 2002
Last updated: June 23, 2005
Last verified: August 2002
  Purpose

This study will determine the pathways between Mohawk cultural identification and specific behaviors related to pollutant exposure, and determine the effects of these factors and the pollutant exposure on physiologically and socially significant outcomes.


Condition
Thyroid Diseases
Cognition Disorders

Study Type: Observational
Study Design: Observational Model: Defined Population
Time Perspective: Cross-Sectional
Official Title: MOHAWK CULTURE, BEHAVIOR, TOXICANT EXPOSURE AND HEALTH

Resource links provided by NLM:


Further study details as provided by National Institute of Environmental Health Sciences (NIEHS):

Estimated Enrollment: 220
Detailed Description:

Considerable concern now exists over possible effects on human physical and psychological development of endocrine disrupting environmental contaminants such as polychlorinated biphenyls (PCBs). Native American communities are particularly at risk owing to subsistence systems and a cultural ethos involving greater contact with the physical environment. The proposed study follows-up 220 Mohawk adolescents aged 17-21 years, who participated in a previous study when they were 10-16 years old. All adolescents are members of the Mohawk Nation at Akwesasne which is located on the St. Lawrence River and is adjacent to hazardous waste sites where PCBs have contaminated the local ecology. The investigation examines the interrelationship between Mohawk cultural identity, traditional Mohawk customs, behaviors related to toxicant exposure and current toxicant burden. Serum level of PCBs will be assessed by congener specific analysis. The study will determine the relationship of congeners and their hydroxylated metabolites to thyroid function (levels of triiodothyronine, free triiodothyronine, thyroxine, free thyroxine, thyrotropin and anti-thyroid antibodies), and 2) psychosocial outcomes including school behavior and performance, hyperactivity, and adaptation to the community. Data gathered for the past study will be employed to assess variation in metabolism of PCBs, as well as how earlier measures of cognition and hyperactivity relate to 17 year old psychosocial outcomes. Variation in susceptibility to PCB effects will be determined by examining the effects of concurrent toxicant exposure (hexachlorobenzene, Mirex, dichlorodiphenyldichloroethene, lead), diet, and indicators of PCB metabolism, on the focal measures of adult functioning. The proposed study will clarify the causal pathways between culturally identifying behavior, PCB exposure and body burden, thyroid functioning, cognitive functioning, social behavior and school functioning while identifying activities that are important to maintain cultural identify and unrelated to exposure.

  Eligibility

Ages Eligible for Study:   17 Years to 18 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Participation in previous study of Mohawk adolescent well-being is required for participation in this project.

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00043238

Locations
United States, New York
First Environments Research Project Office Recruiting
Akwesasne, New York, United States, 13655
Contact: Agnes Jacobs    518-358-9223      
Sponsors and Collaborators
  More Information

Publications:
ClinicalTrials.gov Identifier: NCT00043238     History of Changes
Other Study ID Numbers: 10904-CP-001
Study First Received: August 7, 2002
Last Updated: June 23, 2005
Health Authority: United States: Federal Government

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):
PCBs
Thyroid
Hyperactivity
School Performance
Mohawk Tribe

Additional relevant MeSH terms:
Cognition Disorders
Thyroid Diseases
Delirium, Dementia, Amnestic, Cognitive Disorders
Mental Disorders
Endocrine System Diseases

ClinicalTrials.gov processed this record on August 21, 2014