DISEASE CHARACTERISTICS:

• Diagnosis of ocular melanoma

  • No melanoma of the iris

• Disease adequately treated by prior surgery (enucleation or tumorectomy) and/or radiotherapy

  • No more than 5 weeks since the beginning of primary tumor treatment

• Measurable disease

  • At least 12.0 mm in largest diameter OR
  • At least 6.0 mm in height
• HLA-A2 positive
• No distant metastases

PATIENT CHARACTERISTICS:

Age:

• Over 18

Performance status:

• ECOG 0-1

Life expectancy:

• Not specified

Hematopoietic:

• Hemoglobin at least 9 g/dL
• Neutrophil count at least 2,000/mm^3
• Lymphocyte count at least 700/mm^3
• Platelet count at least 100,000/mm^3
• No bleeding disorder

Hepatic:

• Bilirubin no greater than 2.0 mg/dL
• AST and ALT no greater than 2 times upper limit of normal (ULN)
• Lactate dehydrogenase no greater than 2 times ULN
• Alkaline phosphatase no greater than 2 times ULN
• Gamma glutamyl transpeptidases no greater than 2 times ULN
• Hepatitis C antibody negative
• Hepatitis B antigen negative

Renal:

• Creatinine no greater than 2.0 mg/dL

Immunologic:

• No clinical immunodeficiency
• No autoimmune diseases
• No inflammatory bowel disease
• No active infection requiring antibiotics
• No multiple sclerosis

Other:

• HIV negative
• No other malignancy except surgically cured carcinoma in situ of the cervix or basal cell or squamous cell carcinoma of the skin
• No other uncontrolled illness
• No psychological, familial, sociological, or geographical conditions that would preclude study participation
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception during and for at least 3 months after study participation

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• No other concurrent immunotherapy or biologic therapy

Chemotherapy:

• No concurrent chemotherapy

Endocrine therapy:

• At least 3 weeks since prior steroids
• No concurrent chronic therapy with high doses of corticosteroids (e.g., methylprednisolone at least 12 mg/day)
• Concurrent topical or inhalation steroids allowed
• No concurrent hormonal therapy

Radiotherapy:

• See Disease Characteristics
• Prior proton beam therapy allowed
• Prior brachytherapy without tumor resection allowed
• Recovered from prior radiotherapy
• No prior radiotherapy to the spleen
• No prior pre-enucleation radiotherapy
• No prior ruthenium Ru 106 as primary therapy alone
• No concurrent radiotherapy

Surgery:

• See Disease Characteristics
• Prior transcleral tumor resection allowed
• Recovered from prior surgery
• No prior major organ allograft
• No prior splenectomy

Other:

• No other concurrent investigational drugs
• No concurrent systemic immunosuppressive drugs