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| Sponsor: | National Center for Research Resources (NCRR) |
|---|---|
| Collaborator: |
Crohn's and Colitis Foundation |
| Information provided by: | National Center for Research Resources (NCRR) |
| ClinicalTrials.gov Identifier: | NCT00035074 |
Purpose
Patients with inflammatory bowel disease (IBD) who require methotrexate (MTX)for treatment currently receive this drug by injection. MTX is also available as a pill that can be given by mouth but it is not known how well the drug enters the body in patients with Crohn's disease or ulcerative colitis. This study is being done to compare how much MTX enters the body when the drug is taken by mouth compared to when it is given by injection. If the drug is well absorbed, it may allow patients to receive the drug by mouth.
| Condition | Intervention |
|---|---|
|
Inflammatory Bowel Disease |
Drug: Methotrexate |
| Study Type: | Interventional |
| Study Design: | Treatment, Crossover Assignment, Bio-availability Study |
| Official Title: | A Pharmacokinetic Study to Determine the Oral Bioavailability of Methotrexate in Patients With Inflammatory Bowel Disease |
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Contacts and Locations
More Information
| Study ID Numbers: | NCRR-M01RR00240-1757 |
| Study First Received: | May 2, 2002 |
| Last Updated: | June 23, 2005 |
| ClinicalTrials.gov Identifier: | NCT00035074 History of Changes |
| Health Authority: | United States: Federal Government |
|
Antimetabolites Antimetabolites, Antineoplastic Immunologic Factors Molecular Mechanisms of Pharmacological Action Antineoplastic Agents Gastrointestinal Diseases Physiological Effects of Drugs Inflammatory Bowel Diseases Enzyme Inhibitors Reproductive Control Agents Folic Acid Antagonists Intestinal Diseases |
Abortifacient Agents, Nonsteroidal Immunosuppressive Agents Pharmacologic Actions Digestive System Diseases Therapeutic Uses Abortifacient Agents Methotrexate Antirheumatic Agents Gastroenteritis Dermatologic Agents Nucleic Acid Synthesis Inhibitors |