Cause of Familial Testicular Cancer
People with a family history of testicular cancer may be at increased risk for the disease.
Genetic and clinical studies of patients with testicular cancer and their family members may help clarify the cause of the disease and identify clinical features.
To characterize the clinical features of testicular cancer.
To identify genes that may lead to increased risk of the disease.
To examine emotional and behavioral issues of members of families at increased risk of the disease.
Males and females from a family with at least two cases of testicular cancer in blood relatives.
Males with testicular cancer in both testicles.
Males with testicular cancer who have an identical twin.
Participants must be at least 12 years of age.
Participants may take part in Part 1 or Parts 1 and 2 of this 2-part study.
Part 1 participants:
- Provide a blood or cheek cell sample to obtain DNA for gene studies.
- Provide permission for researchers to obtain their medical records for review.
- Complete questionnaires about their personal and family medical history, exposure to factors that might influence the risk of testicular cancer, and their feelings about being a member of a family in which several members have testicular cancer.
- These data are collected from participants in their home communities.
Part 2 participants:
- All participants provide a medical history, have a complete physical examination, including routine lab tests, and have an ultrasound test of the abdomen to look at the kidneys.
- Males have an ultrasound test of the testicles and scrotum.
- Females have an ultrasound test of the pelvis to look at the ovaries, uterus and fallopian tubes.
- Males 18 years of age and older provide a semen sample.
- Some participants have computed tomography (CT) scanning of the chest, abdomen and pelvis instead of kidney ultrasound. Children under 18 years of age may have magnetic resonance imaging (MRI) instead of CT.
- These data are collected from participants during a 2-day visit to the NIH Clinical Center in Bethesda, MD. Travel costs are covered by the protocol.
|Official Title:||Multidisciplinary Etiologic Study of Familial Testicular Cancer|
- Ascertain new familiies with FTGCTs [ Time Frame: ongoing ] [ Designated as safety issue: No ]
- Characterize the clinical features of familial TGC [ Time Frame: ongoing ] [ Designated as safety issue: No ]
- Determine the underlying genetic mechanism for susceptibility to TGCT in families [ Time Frame: ongoing ] [ Designated as safety issue: No ]
- Evaluate psychosocial issues related to FGCT [ Time Frame: ongoing ] [ Designated as safety issue: No ]
|Study Start Date:||April 2002|
|Contact: Jennifer T Loud, C.R.N.P.||(301) email@example.com|
|United States, Maryland|
|National Institutes of Health Clinical Center, 9000 Rockville Pike||Recruiting|
|Bethesda, Maryland, United States, 20892|
|Contact: For more information at the NIH Clinical Center contact National Cancer Institute Referral Office (888) NCI-1937|
|Principal Investigator:||Jennifer T Loud, C.R.N.P.||National Cancer Institute (NCI)|